POCUMINT

Proof Of Concept Use of MTH1 Inhibitors as New Treatments for cancer

Coordinatore	KAROLINSKA INSTITUTET    more Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.
Nazionalità Coordinatore	Sweden [SE]
Totale costo	164˙795 €
EC contributo	150˙000 €
Programma	FP7-IDEAS-ERC Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	ERC-2013-PoC
Funding Scheme	CSA-SA(POC)
Anno di inizio	2014
Periodo (anno-mese-giorno)	2014-05-01   -   2015-04-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	KAROLINSKA INSTITUTET INNOVATIONS AB  Organization address address: TOMTEBODAVAGEN 23 A city: SOLNA postcode: 171 65 contact info Titolo: Dr. Nome: Christian Cognome: Krog-Jensen Email: send email Telefono: 46706618149	SE (SOLNA)	beneficiary	44˙010.00
2	KAROLINSKA INSTITUTET  Organization address address: Nobels Vag 5 city: STOCKHOLM postcode: 17177 contact info Titolo: Mrs. Nome: Jill Cognome: Blomstrand Email: send email Telefono: 46852487687	SE (STOCKHOLM)	hostInstitution	105˙990.00

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 Obiettivo del progetto (Objective)

'In our ERC grant GEnetic NEtworks as a tool for anti-CAncer Drug Development we used phenotypic screening and genetic networks to identify the DNA repair protein MTH1 as a critical component for cancer cell survival and we developed selective sub nM inhibitors to MTH1, which specifically kill cancer cells and tumours, whilst being less toxic to primary cells. Our approach provides a novel concept for treating cancer. Here, we want to explore the commercial potential of the MTH1 inhibitors identified in the ERC grant.'