MICRODEGRADE

Identifying and Overcoming Bottlenecks of Micropollutant Degradation at Low Concentrations

Coordinatore	HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH    more Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.
Nazionalità Coordinatore	Germany [DE]
Totale costo	1˙962˙630 €
EC contributo	1˙962˙630 €
Programma	FP7-IDEAS-ERC Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	ERC-2013-CoG
Funding Scheme	ERC-CG
Anno di inizio	2014
Periodo (anno-mese-giorno)	2014-05-01   -   2019-04-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH  Organization address address: Ingolstaedter Landstrasse 1 city: MUENCHEN postcode: 85764 contact info Titolo: Dr. Nome: Jürgen Cognome: Ertel Email: send email Telefono: +49 89 3187 3022	DE (MUENCHEN)	hostInstitution	1˙962˙630.00
2	HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH  Organization address address: Ingolstaedter Landstrasse 1 city: MUENCHEN postcode: 85764 contact info Titolo: Dr. Nome: Martin Cognome: Elsner Email: send email Telefono: +49 8931872565	DE (MUENCHEN)	hostInstitution	1˙962˙630.00

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 Obiettivo del progetto (Objective)

'MicroDegrade aims to reveal bottlenecks of degradation, and to identify superior bioremediation strategies for a most notorious environmental pollution of our time: chemical micropollutants at low (sub-ug/L) concentrations. Finding out why micropollutants occur in ground and surface water despite the presence of bacterial degraders has become an elusive goal for microbiologists, environmental scientists and geochemists. Competing paradigms claim that either (i) mass transfer limitations (bioavailability, cell uptake) or (ii) physiological limitations (enzyme down-regulation) prevent complete biodegradation at contaminant threshold concentrations. To design strategies for remediation, insight is warranted which bottlenecks of degradation prevail. 'Do molecules - once inside an organism - get out into solution again? Or is mass transfer so limiting that organisms are desperate for supply?' Pillaring on our recent advances with compound-specific isotope analysis at sub-ug/L concentrations, MicroDegrade will be able to provide a revolutionary angle on this dilemma. Isotope fractionation will give the first direct answers to these questions for degradation of two prominent pollutants at low bacterial growth and low concentrations - 2,6-dichlorobenzamide (BAM), a highly recalcitrant, ubiquitous pesticide metabolite with Aminbacter MSH1; and toluene, an abundant groundwater pollutant with Geobacter metallireducens. The approach pillars on three consecutive aims: (1) investigate if, and at what concentrations mass transfer becomes limiting in chemostat cultures; (2) understand analogous limitations in concentrations gradients of an aquifer model; (3) derive superior bioremediation strategies. The objectives of MicroDegrade have the potential to change our view on drivers behind thresholds values and bottlenecks of degradation, to offer a new angle on competitive strategies of microorganisms at low concentrations, and to identify superior future bioremediation strategies.'