METAFIGHT

Understanding and fighting metastasis via dissection of the Core Invasive Machinery

Coordinatore	UNIVERSITA DEGLI STUDI DI TORINO    more  Organization address address: Via Giuseppe Verdi 8 city: TORINO postcode: 10124 contact info Titolo: Dr. Nome: Alberto Cognome: Giuranna Email: send email Telefono: -116707858 Fax: -116707856
Nazionalità Coordinatore	Italy [IT]
Sito del progetto	http://www.metafight.eu/
Totale costo	3˙946˙206 €
EC contributo	2˙999˙609 €
Programma	FP7-HEALTH Specific Programme "Cooperation": Health
Code Call	FP7-HEALTH-2007-A
Funding Scheme	CP-FP
Anno di inizio	2008
Periodo (anno-mese-giorno)	2008-01-01   -   2010-12-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	UNIVERSITA DEGLI STUDI DI TORINO  Organization address address: Via Giuseppe Verdi 8 city: TORINO postcode: 10124 contact info Titolo: Dr. Nome: Alberto Cognome: Giuranna Email: send email Telefono: -116707858 Fax: -116707856	IT (TORINO)	coordinator	0.00
2	"PHARMAMAR, S.A.U."  Organization address address: "Avda. de los Reyes , Poligono Industrial La Mina 1" city: COLMENAR VIEJO (MADRID) postcode: 28770 contact info Titolo: Ms. Nome: Elena Cognome: Calleja Email: send email Telefono: 34918466000 Fax: + 34 91 846 6001	ES (COLMENAR VIEJO (MADRID))	participant	0.00
3	AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS  Organization address address: CALLE SERRANO 117 city: MADRID postcode: 28006 contact info Titolo: Ms. Nome: Mar Cognome: García-Ferrer Email: send email Telefono: 0034 91 5854984 Fax: 0034 91 5855360	ES (MADRID)	participant	0.00
4	ARTTIC  Organization address address: Rue du Dessous des Berges 58A city: PARIS postcode: 75013 contact info Titolo: Dr. Nome: Eric Cognome: Papon Email: send email Telefono: -53945432 Fax: +33 1 53 94 54 70	FR (PARIS)	participant	0.00
5	FUNDACION DE INVESTIGACION DEL CANCER DE LA UNIVERSIDAD DE SALAMANCA  Organization address address: Campus Miguel de Unamuno city: SALAMANCA postcode: 37007 contact info Titolo: Mr. Nome: Antonio Cognome: Mata Email: send email Telefono: +34 923294784 Fax: +34 923294743	ES (SALAMANCA)	participant	0.00
6	KAROLINSKA INSTITUTET  Organization address address: Nobels Vag 5 city: STOCKHOLM postcode: 17177 contact info Titolo: Ms. Nome: Cecilia Cognome: Tilly Email: send email Telefono: +46 86089103 Fax: +46 86089280	SE (STOCKHOLM)	participant	0.00
7	KDEV EXPLORATORY AB  Organization address address: NOBELS VAEG 3 city: STOCKHOLM postcode: 171 77 contact info Titolo: Ms. Nome: Eva Cognome: Montgomerie Email: send email Telefono: +46 (8) 524 84 801 Fax: +46 (8) 524 84 800	SE (STOCKHOLM)	participant	0.00
8	MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.  Organization address address: Hofgartenstrasse 8 city: MUENCHEN postcode: 80539 contact info Titolo: Ms. Nome: Ulrike Cognome: Jendis Email: send email Telefono: +49 89 85783869 Fax: +49 89 85782235	DE (MUENCHEN)	participant	0.00
9	TURUN YLIOPISTO  Organization address address: YLIOPISTONMAKI city: TURUN YLIOPISTO postcode: 20014 contact info Titolo: Dr. Nome: Eliisa Cognome: Särkilahti Email: send email Telefono: +358 2 3336155 Fax: +358 2 3336446	FI (TURUN YLIOPISTO)	participant	0.00
10	UNIVERSITEIT LEIDEN  Organization address address: RAPENBURG 70 city: LEIDEN postcode: 2300 RA contact info Titolo: Mr. Nome: Ton Cognome: Brouwer Email: send email Telefono: +31 71 527 3149 Fax: +31 71 527 5269	NL (LEIDEN)	participant	0.00

Mappa

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 Obiettivo del progetto (Objective)

'The co-operative Metafight project will perform functional studies to understand the dissemination and outgrowth of metastasis through systematic analysis of the Core Invasive Machinery contained within integrin-mediated ECM attachment structure. It includes a large and discretely localised intracellular signalling network which drives migration and invasion. Our strategy is based on the hypothesis that metastatic cells arise from molecular changes that alter the primary tumour architecture as well as the tumor microenvironment, by reversible modulation of cell adhesion, onset of signalling pathways and acquisition of novel migratory and invasive capacities. The Metafight Consortium is strengthened by established combined expertise on adhesion receptor signalling and availability of unique tumor cell and cancer animal model systems. We will characterise known and novel components of the Core Invasive Machinery, responsible for development and homing of metastasis, by innovative in vivo non-invasive imaging techniques. The Metafight project comprises seven major interrelated Work Packages (WP). WP1 is designed to investigate the molecular and functional architecture of the Core Invasive Machinery, from which depends tumour cell migration and eventually invasion. WP2 and WP3 screen for key modulators of metastasis formation in in vivo murine models, by non-invasive imaging techniques. WP4 is related to a comprehensive proteomic analysis of expression and phosphorylation of our candidate modulators in metastasis formation. WP1-4 feed into WP5, which builds upon and exploits knowledge generated in the first four WPs and translates it into existing pharmacological interventions to generate new candidate drugs. This will lead to patent filing and licensing strategies. WP6 and WP7 handle dissemination and management activities. The ultimate accomplishment will include improvement of health, reduction of health expenses, as well as creation of new jobs and economic benefit.'

Introduzione (Teaser)

One of the hallmarks of cancer is its ability to leave the original site and colonise distant organs, a process known as metastasis. Understanding the complex mechanisms and interactions between a cancer cell and its surroundings are of paramount importance in the fight against cancer.