STAR-T REK
Set up and comparison of multiple stem cell approaches for kidney repair
| Coordinatore | UNIVERSITA DEGLI STUDI DI FIRENZE
Organization address
address: Piazza San Marco 4 contact info |
| Nazionalità Coordinatore | Italy [IT] |
| Totale costo | 4˙052˙900 € |
| EC contributo | 2˙999˙500 € |
| Programma | FP7-HEALTH
Specific Programme "Cooperation": Health |
| Code Call | FP7-HEALTH-2007-B |
| Funding Scheme | CP-FP |
| Anno di inizio | 2008 |
| Periodo (anno-mese-giorno) | 2008-11-01 - 2011-10-31 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
UNIVERSITA DEGLI STUDI DI FIRENZE
Organization address
address: Piazza San Marco 4 contact info |
IT (Florence) | coordinator | 0.00 |
| 2 |
ACADEMISCH ZIEKENHUIS LEIDEN
Organization address
address: Albinusdreef 2 contact info |
NL (LEIDEN) | participant | 0.00 |
| 3 |
ALTA RICERCA E SVILUPPO IN BIOTECNOLOGIE SRLU
Organization address
address: VIA FIORENTINA 151 contact info |
IT (SIENA) | participant | 0.00 |
| 4 |
ARETA INTERNATIONAL SRL
Organization address
address: VIALE REGINA GIOVANNA 17 contact info |
IT (MILANO) | participant | 0.00 |
| 5 |
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
Organization address
address: 101 Rue de Tolbiac contact info |
FR (PARIS) | participant | 0.00 |
| 6 |
ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI
Organization address
address: Via Giuseppe La Masa 19 contact info |
IT (MILANO) | participant | 0.00 |
| 7 |
MILTENYI BIOTEC GMBH
Organization address
address: FRIEDRICH EBERT STRASSE 68 contact info |
DE (BERGISCH GLADBACH) | participant | 0.00 |
| 8 |
OULUN YLIOPISTO
Organization address
address: Pentti Kaiteran Katu 1 contact info |
FI (OULU) | participant | 0.00 |
| 9 |
THE UNIVERSITY OF EDINBURGH
Organization address
address: OLD COLLEGE, SOUTH BRIDGE contact info |
UK (EDINBURGH) | participant | 0.00 |
| 10 |
UNIVERSITAETSKLINIKUM AACHEN
Organization address
address: Pauwelsstrasse 30 contact info |
DE (AACHEN) | participant | 0.00 |
| 11 |
WEIZMANN INSTITUTE OF SCIENCE
Organization address
address: HERZL STREET 234 contact info |
IL (REHOVOT) | participant | 0.00 |
Mappa
Word cloud
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Obiettivo del progetto (Objective)
'With the increasing rate of end-stage renal failure and limited alternatives for its treatment, potential regenerative approaches for kidney damages are urgently needed. Because of the complexity of the organ, the development of stem cell therapies for kidney is still in its infancy. Identifying which cell types are capable of beneficial effects is the critical step required to realize the potential of this therapeutic approach. Three possible sources of stem cells can be envisioned for the development of this type of treatment: (i) bone-marrow-derived stem cells, (ii) renal adult stem cells, and (iii) fetal renal stem cells. The focus of this project is to assess the regenerative potential of stem cells derived from different sources and investigate the possible obstacles to their utilization, as well as their potential side effects in preclinical models of acute and chronic renal failure. Indeed, the clinical usefulness of the treatment, as well as the need to understand currently discrepant results, require comparative experimental studies that have never been performed before either in SC therapy of kidney injury, or in that of other organs. Hopefully, this comparison will allow to set up standardized protocols of SC isolation and administration for phase I/II trials in patients affected by acute and chronic renal failure.'
Introduzione (Teaser)
EU researchers have made important progress towards producing tissue-engineered kidneys. With the ever-increasing demand for kidney transplants, new stem cell approaches for kidney tissue regeneration are needed urgently.