MCI-AD

"Natural history of Mild Cognitive Impairment and Alzheimer’s Disease: factors influencing early detection, clinical course, and prognosis."

Coordinatore	FONDAZIONE SANTA LUCIA    more  Organization address address: VIA ARDEATINA 306 city: Roma postcode: 179 contact info Titolo: Dr. Nome: Antonio Cognome: Ierna Email: send email Telefono: 390652000000 Fax: 390652000000
Nazionalità Coordinatore	Italy [IT]
Totale costo	162˙985 €
EC contributo	162˙985 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2007-2-1-IEF
Funding Scheme	MC-IEF
Anno di inizio	2008
Periodo (anno-mese-giorno)	2008-04-01   -   2010-03-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	FONDAZIONE SANTA LUCIA  Organization address address: VIA ARDEATINA 306 city: Roma postcode: 179 contact info Titolo: Dr. Nome: Antonio Cognome: Ierna Email: send email Telefono: 390652000000 Fax: 390652000000	IT (Roma)	coordinator	0.00

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 Obiettivo del progetto (Objective)

'Background: There has been great interest in identifying persons at high risk of developing Alzheimer disease (AD) and dementia, as they should constitute a target group for possible prevention or early treatment of dementia in the future. Mild Cognitive Impairment (MCI) is a transitional zone between normal cognitive function and clinical AD. The MCI syndrome is characterized by subjective memory problems and memory deficits. Persons with MCI have an increased risk of developing dementia but some are stable or even recover, while others have an increased risk of death. As not all subjects with MCI progress to dementia, there is a need to examine factors that determine which MCI subjects will develop dementia. Aims/implementation: The main aims include to: 1) identify predictors of AD in the early, prediagnostic phase of the disease; 2) evaluate prognostic factors in patients with MCI; 3) explore the natural history of AD and other dementias and; 4) assess the occurrence of behavioral and psychological symptoms in dementia. The two-year Fellowship will be conducted at the Santa Lucia Foundation, Rome, and the Italian National Research Council, Institute of Biomedical Technologies, Milan. Three Italian, multi-center, clinical cohort studies on patients with AD and MCI will be investigated: 1) Behavioral and Psychological Symptoms of Dementia (BPSD) multi-center Italian study, including 1015 patients with AD; 2) The Italian Dementia Study, a multi-center clinical study of 1550 patients with MCI, AD and other dementias and; 3) The Italian Network on AD, MCI study, including 270 subjects with MCI, who were referred to 21 neurological centers around Italy in 2000-1. Relevance: The current project might have considerable implications n public health and understanding the natural history of degenerative diseases. Detecting syndromes associated with an early AD phase will enable earlier treatment, healthcare planning, and the postponement of institutionalization.'