PROACTIVE

High Throughput Proteomics Systems for Accelerated Profiling of Putative Plasma Biomarkers

Coordinatore	OLINK AB    more  Organization address address: UPPSALA SCIENCE PARK city: UPPSALA postcode: 751 83 contact info Titolo: Dr. Nome: Simon Cognome: Fredriksson Email: send email Telefono: +46 (0)18 - 444 39 84 Fax: -+46 (0)18 - 50 93 00
Nazionalità Coordinatore	Sweden [SE]
Totale costo	3˙950˙800 €
EC contributo	2˙989˙800 €
Programma	FP7-HEALTH Specific Programme "Cooperation": Health
Code Call	FP7-HEALTH-2007-B
Funding Scheme	CP-TP
Anno di inizio	2008
Periodo (anno-mese-giorno)	2008-10-01   -   2011-09-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	OLINK AB  Organization address address: UPPSALA SCIENCE PARK city: UPPSALA postcode: 751 83 contact info Titolo: Dr. Nome: Simon Cognome: Fredriksson Email: send email Telefono: +46 (0)18 - 444 39 84 Fax: -+46 (0)18 - 50 93 00	SE (UPPSALA)	coordinator	0.00
2	FUJIREBIO DIAGNOSTICS AB  Organization address address: ELOF LINDALVS GATA 13 city: GOETEBORG postcode: 402 42 contact info Titolo: Dr. Nome: Olle Cognome: Nilsson Email: send email Telefono: +46 (0) 31 85 70 34 Fax: +46 (0)31 85 70 40	SE (GOETEBORG)	participant	0.00
3	INNOVA BIOSCIENCES LIMITED  Organization address address: BABRAHAM HALL city: CAMBRIDGE postcode: CB22 3AT contact info Titolo: Dr. Nome: Nick Cognome: Gee Email: send email Telefono: +44(0)1223 496170 Fax: +44(0)1223 496172	UK (CAMBRIDGE)	participant	0.00
4	INTEGROMICS SL ITG  Organization address address: AVENIDA DE INNOVACION GRANADA PARQUE TECNOLOGIA CIENCAS DE LA SALUD 1 BIC city: ARMILLA -GRANADA postcode: 18100 contact info Titolo: Mr. Nome: Marco Cognome: Rodriguez Junker Email: send email Telefono: 34915855305 Fax: 34913720112	ES (ARMILLA -GRANADA)	participant	0.00
5	KOBENHAVNS UNIVERSITET	DK	participant	0.00
6	UPPSALA UNIVERSITET  Organization address address: SANKT OLOFSGATAN 10 B city: UPPSALA postcode: 751 05 contact info Titolo: Ms. Nome: Margareta Cognome: Uvhagen Email: send email Telefono: +46-18-471 6312 Fax: +46-18-471 19 82	SE (UPPSALA)	participant	0.00

Mappa

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 Obiettivo del progetto (Objective)

'The PROACTIVE consortium will through research and innovation develop the multiplexed proximity ligation assay into a high throughput protein detection and quantification technology along with novel data management and analysis tools. Hundreds of putative biomarkers of the plasma proteome can then be assayed with high sensitivity in minute sample volumes, far surpassing any current capabilities. This consortium combines three SMEs across Europe with synergistic competences in technology development, reagent manufacturing, and software development for data management and analysis. Together with clinical cancer scientists, biostatisticians, and diagnostics industry, these high capacity tools will be evaluated in pilot projects for cancer biomarkers using biobanked samples. Preliminary data in the literature claim improved diagnostics with the use of multiple complementary protein markers. However, there is a lack of suitable high throughput procedures for finding new markers and discovering which markers complement each other into effective diagnostic panels. Better capabilities to diagnose cancer at the early and most curable stages will greatly improve human health and reduce health care costs. Patient stratification is also in need of better diagnostics to facilitate the selection of appropriate patient care. Many clinically used immunoassays capable of diagnosing cancer have been in use for many years as single markers but with limited sensitivity and specificity. No marker can today single-handedly diagnose all cases with desired accuracy for a certain cancer type. Also, the performance of these markers is decreased for the earliest stages of the disease. At the conclusion of this collaborative project, the research and innovation conducted within the consortium will enable the partners to position themselves at the very fore-front of high-throughput biomarker research strengthening their competitiveness in the international arena.'

Introduzione (Teaser)

The prospect of being able to analyse hundreds of low-abundance proteins in blood samples would lead to improved disease detection and prompt diagnosis. Researchers of the PROACTIVE consortium aimed to make this a reality by developing a multiplex proximity ligation assay (PLA) that could simultaneously detect multiple proteins from blood.