DISC REGENERATION
Novel biofunctional high porous polymer scaffolds and techniques controlling angiogenesis for the regeneration and repair of the degenerated intervertebral disc
| Coordinatore | CONSIGLIO NAZIONALE DELLE RICERCHE
Organization address
address: Piazzale Aldo Moro 7 contact info |
| Nazionalità Coordinatore | Italy [IT] |
| Sito del progetto | http://www.disc-regeneration.eu/ |
| Totale costo | 9˙422˙854 € |
| EC contributo | 6˙977˙150 € |
| Programma | FP7-NMP
Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies |
| Code Call | FP7-NMP-2007-LARGE-1 |
| Funding Scheme | CP-IP |
| Anno di inizio | 2008 |
| Periodo (anno-mese-giorno) | 2008-11-01 - 2012-10-31 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
CONSIGLIO NAZIONALE DELLE RICERCHE
Organization address
address: Piazzale Aldo Moro 7 contact info |
IT (ROMA) | coordinator | 0.00 |
| 2 |
ANIKA THERAPEUTICS SRL
Organization address
address: VIA PONTE DELLA FABBRICA 3B contact info |
IT (ABANO TERME) | participant | 0.00 |
| 3 |
FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA
Organization address
address: CARRER BALDIRI REIXAC PLANTA 2A 10-12 contact info |
ES (BARCELONA) | participant | 0.00 |
| 4 |
INEB-INSTITUTO NACIONAL DE ENGENHARIA BIOMEDICA ASSOCIACAO
Organization address
address: PRACA GOMES TEIXEIRA contact info |
PT (PORTO) | participant | 0.00 |
| 5 |
KATHOLIEKE UNIVERSITEIT LEUVEN
Organization address
address: Oude Markt 13 contact info |
BE (LEUVEN) | participant | 0.00 |
| 6 |
KING'S COLLEGE LONDON
Organization address
address: Strand contact info |
UK (LONDON) | participant | 0.00 |
| 7 |
NATIONAL UNIVERSITY OF IRELAND, GALWAY
Organization address
address: University Road - contact info |
IE (GALWAY) | participant | 0.00 |
| 8 |
SOCIETA AZIONARIA MATERIALE OSPEDALIERO SAMO SPA
Organization address
address: VIA MATTEOTTI 37 contact info |
IT (GRANAROLO DELL EMILIA) | participant | 0.00 |
| 9 |
SWEREA IVF AB
Organization address
address: Argongatan 30 contact info |
SE (MOELNDAL) | participant | 0.00 |
| 10 |
UNIVERSIDAD DE ALICANTE
Organization address
address: CAMPUS DE SAN VICENTE RASPEIG s/n contact info |
ES (ALICANTE) | participant | 0.00 |
| 11 |
UNIVERSIDADE DO MINHO
Organization address
address: Largo do Paco contact info |
PT (BRAGA) | participant | 0.00 |
| 12 |
UNIVERSITA DEGLI STUDI DI PADOVA
Organization address
address: VIA 8 FEBBRAIO 2 contact info |
IT (PADOVA) | participant | 0.00 |
| 13 |
UNIVERSITAET ULM
Organization address
address: HELMHOLTZSTRASSE 16 contact info |
DE (ULM) | participant | 0.00 |
| 14 |
UNIVERSITAETSSPITAL BASEL
Organization address
address: HEBELSTRASSE 32 contact info |
CH (BASEL) | participant | 0.00 |
| 15 |
UNIVERSITATEA POLITEHNICA DIN BUCURESTI
Organization address
address: SPLAIUL INDEPENDENTEI 313 contact info |
RO (BUCURESTI) | participant | 0.00 |
| 16 |
UNIVERSITATSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITAT MAINZ
Organization address
address: Langenbeckstrasse 1 contact info |
DE (Mainz) | participant | 0.00 |
| 17 |
UNIVERSITY OF BRIGHTON
Organization address
address: "Lewes Road, Mithras House" contact info |
UK (BRIGHTON) | participant | 0.00 |
Mappa
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Obiettivo del progetto (Objective)
'30% of European workers experience back pain, and it is the most frequently reported work-related disorder. The proposed work seeks to provide a cure for lower back pain by developing porous scaffolds and technology which will repair a damaged intervertebral disc (IVD) by enabling its regeneration to a natural healthy state or better. Injectable acellular and cell-loaded bioactive polymer-based scaffolds will be developed. These will be designed to be implanted into the patient by minimally invasive surgery. A biomimetic approach will confer the appropriate mechanical and biological properties and enable the inclusion of the requisite cell signalling factors to produce a bio-hybrid structure which closely resembles the human tissue in all its essential attributes. Particular attention will be paid to angiogenesis. In IVD tissue, vascularization must be carefully controlled, due to the unique anatomy and physiology of the intervertebral disc. There must be negligible vascularization in the annulus and nucleus regions and moderate vascularization at the vertebral body level. Work will therefore be performed on materials functionalization, and on growth factor incorporation and delivery, to enable this region-specific control of vascularization at different levels. Natural IVD tissue contains a relatively low number of cells, which are chondrocyte-like in character. Consequently, it will be necessary to devote some research to identifying and evaluating suitable and more readily available alternative cells for incorporation in the bio-hybrid substitutes produced . Modelling studies will identify the physical and mechanical properties of the natural IVD and the substitute materials, and provide an understanding of the physical aspects of the regeneration process. In vivo study on animal model will be performed the bio-fuctionality of both sustitutes. Surgical methodology and protocol will be developed.'