NOTCHIT

NOTCH SIGNALING IN DEVELOPMENT AND PATHOLOGY

Coordinatore	UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA    more  Organization address address: Piazzale Aldo Moro 5 city: ROMA postcode: 185 contact info Titolo: Mr. Nome: Giancarlo Cognome: Bertea Email: send email Telefono: +39 06 49271320 Fax: +39 06 49271329
Nazionalità Coordinatore	Italy [IT]
Totale costo	3˙460˙000 €
EC contributo	3˙460˙000 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2007-1-1-ITN
Funding Scheme	MC-ITN
Anno di inizio	2009
Periodo (anno-mese-giorno)	2009-01-01   -   2012-12-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA  Organization address address: Piazzale Aldo Moro 5 city: ROMA postcode: 185 contact info Titolo: Mr. Nome: Giancarlo Cognome: Bertea Email: send email Telefono: +39 06 49271320 Fax: +39 06 49271329	IT (ROMA)	coordinator	716˙306.80
2	THE UNIVERSITY OF EDINBURGH  Organization address address: OLD COLLEGE, SOUTH BRIDGE city: EDINBURGH postcode: EH8 9YL contact info Titolo: Ms. Nome: Angela Cognome: Noble Email: send email Telefono: +44 131 650 9024 Fax: +44 131 650 9023	UK (EDINBURGH)	participant	510˙686.00
3	KAROLINSKA INSTITUTET  Organization address address: Nobels Vag 5 city: STOCKHOLM postcode: 17177 contact info Titolo: Ms. Nome: Riitta Cognome: Ljungström Email: send email Telefono: +46 8 52487321 Fax: +46 8 33 93 80	SE (STOCKHOLM)	participant	446˙285.40
4	ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE  Organization address address: BATIMENT CE 3316 STATION 1 city: LAUSANNE postcode: 1015 contact info Titolo: Ms. Nome: Catherine Cognome: Pache Email: send email Telefono: +41 21 692 58 87 Fax: +41 652 69 33	CH (LAUSANNE)	participant	444˙347.70
5	FUNDACION CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CARLOS III  Organization address address: C/ MELCHOR FERNANDEZ ALMAGRO 3 city: MADRID postcode: 28029 contact info Titolo: Dr. Nome: Stefan Cognome: Jungbluth Email: send email Telefono: 34914531200 Fax: 34914531245	ES (MADRID)	participant	419˙648.90
6	INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)  Organization address address: 101 Rue de Tolbiac city: PARIS postcode: 75654 contact info Titolo: Ms. Nome: Isabelle Cognome: Lopes Email: send email Telefono: 33155260450 Fax: 33155260486	FR (PARIS)	participant	401˙953.20
7	KDEV EXPLORATORY AB  Organization address address: NOBELS VAEG 3 city: STOCKHOLM postcode: 171 77 contact info Titolo: Dr. Nome: Jonas Cognome: Ekstrand Email: send email Telefono: +46 70 302 08 96 Fax: +46 8 524 848 00	SE (STOCKHOLM)	participant	330˙008.90
8	INSTITUT PASTEUR  Organization address address: RUE DU DOCTEUR ROUX 25-28 city: PARIS CEDEX 15 postcode: 75724 contact info Titolo: Dr. Nome: Nadia Cognome: Khelef Email: send email Telefono: +33 1 40 61 33 78 Fax: +33 1 40 61 39 40	FR (PARIS CEDEX 15)	participant	190˙763.10
9	AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS  Organization address address: CALLE SERRANO 117 city: MADRID postcode: 28006 contact info	ES (MADRID)	participant	0.00
10	NEWRON SWEDEN AB  Organization address address: FISKARTORPSVAGEN 15 A D city: STOCKHOLM postcode: 114 33 contact info Titolo: Mr. Nome: Henrik Cognome: Resmark Email: send email Telefono: +46 8 786 0900 Fax: +46 8 786 0911	SE (STOCKHOLM)	participant	0.00

Mappa

 Word cloud

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 Obiettivo del progetto (Objective)

'Eight partners from six different EU countries will converge in NotchIT, a multi-site ITN aimed to increase the knowledge of cellular and molecular mechanisms by which Notch signaling regulates the development and pathology of different tissues. Notch signaling plays a key role in cell-fate determination and differentiation of various cell types and aberrant Notch signaling is associated with pathogenesis of different human diseases, including cancer. NotchIT integrates the research and training activities of the eight different partners, who are all leaders in Notch signaling and related fields, to specifically address three strategic initiatives, which are central to European science and health economy: - the core Notch signaling mechanism with the purpose of constructing a state-of-the-art molecular tool box for Notch signaling and to disseminate this knowledge and reagents at a pan-European level. - the role of Notch signaling in the differentiation and pathology of various cell types with the purpose of using Notch signaling to improve our means to steer stem cell differentiation and to correct aberrant Notch signaling in pathologies. - how Notch signaling can be exogenously controlled through pharmacological approaches, in order to break new ground and to ultimately design new diagnostic and therapeutic protocols. The training component in NotchIT is deeply integrated with the research programme. The partners in NotchIT possess a wide range of expertise and work in operationally diverse environments: Hospitals, Universities, Research Institutes and Industry. This broad knowledge-base, combined with an integrated set of courses, workshops, meetings and cross-laboratory visits, provides an excellent training opportunity for early stage and experienced scientists in the center, and will prepare them for high level positions in academia and industry.'

Introduzione (Teaser)

Notch signalling is a highly conserved pathway that plays a key role in cell-fate determination and differentiation of various cell types. European scientists have teamed up to delineate the Notch pathway and find its association with disease.