STPKINTB

Protein kinases in metabolic regulation in Mycobacterium tuberculosis

Coordinatore	UNIVERSITY OF LEICESTER    more  Organization address address: University Road city: LEICESTER postcode: LE1 7RH contact info Titolo: Ms. Nome: Marie Cognome: Adams Email: send email Telefono: +44 116 223 1799 Fax: +44 116 252 2028
Nazionalità Coordinatore	United Kingdom [UK]
Totale costo	45˙000 €
EC contributo	45˙000 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-ERG-2008
Funding Scheme	MC-ERG
Anno di inizio	2008
Periodo (anno-mese-giorno)	2008-11-01   -   2012-04-29

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	UNIVERSITY OF LEICESTER  Organization address address: University Road city: LEICESTER postcode: LE1 7RH contact info Titolo: Ms. Nome: Marie Cognome: Adams Email: send email Telefono: +44 116 223 1799 Fax: +44 116 252 2028	UK (LEICESTER)	coordinator	45˙000.00

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 Obiettivo del progetto (Objective)

'The genome of Mycobacterium tuberculosis contains 11 serine threonine protein kinases. Amongst these PknA, PknB and PknG are essential for bacterial survival and/or virulence, and are considered potential drug targets. This proposal aims to elucidate the functions of PknB and PknG, with particular focus on the regulation of primary metabolism. PknB is reported to be involved in the control of cell-shape, whereas PknG might function as a regulator of metabolism or as a virulence protein secreted into the macrophage. Based on a study of the related microbe Corynebacterium glutamicum, preliminary work has been done to investigate a possible role for PknG (and possibly PknB) in regulation of the citric acid cycle. In corynebacteria PknG controls the phosphorylation status of a small regulatory protein GarA, which directly inhibits the ODH complex. First experiments with mycobacteria suggest that this regulatory mechanism is probably conserved and may also be employed to regulate nitrogen metabolism in these organisms. An experimental strategy is proposed to investigate the regulation of kinase activity and determine the effects of kinase activity on carbon and nitrogen metabolism.'