PSIEMBL

Functional and evolutionary studies of the glutamatergic synapse; a proteomic and genetic approach

Coordinatore	GENOME RESEARCH LIMITED    more  Organization address address: THE GIBBS BUILDING, EUSTON ROAD 215 city: LONDON postcode: NW1 2BE contact info Titolo: Mr. Nome: David Cognome: Davison Email: send email Telefono: +44 (0)1223 494937 Fax: +44 (0)1223 494919
Nazionalità Coordinatore	United Kingdom [UK]
Totale costo	233˙785 €
EC contributo	233˙785 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2007-2-1-IEF
Funding Scheme	MC-IEF
Anno di inizio	2009
Periodo (anno-mese-giorno)	2009-02-01   -   2011-01-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	GENOME RESEARCH LIMITED  Organization address address: THE GIBBS BUILDING, EUSTON ROAD 215 city: LONDON postcode: NW1 2BE contact info Titolo: Mr. Nome: David Cognome: Davison Email: send email Telefono: +44 (0)1223 494937 Fax: +44 (0)1223 494919	UK (LONDON)	coordinator	0.00

Mappa

 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

 Obiettivo del progetto (Objective)

'Glutamatergic neurons are the main excitatory nerve cells in the central nervous system of mammals, in this project we aim to better understand the molecular composition of their synapses. We are particularly interested in the post synapse and the complexes of proteins associated to the NMDA glutamate receptor. We are focused in this set of molecules since the NMDA receptor is central for the establishment of synaptic plasticity, a physiological property of neurons which is believed to be necessary for learning and memory, the cognitive process we are interested in. The general objectives of this project are three: 1. Understanding the molecular basis of learning and memory through combined genetic and proteomic approaches. 2. Understanding the evolution of the synapse by studying species differences. 3. Characterising the human hippocampal glutamatergic synapse. These objectives will be addressed using a combination of proteomic and bioinformatic systems biology. In all cases we will isolate the protein complexes of interest and investigate its molecular composition by mass spectrometry. For the first objective we want to compare wild type mice with a series of KO for important proteins in learning and memory; we expect to better understand the role of the KO molecules in those cognitive processes. We also want to study the evolution of the glutamatergic synapse; we propose to characterize the same set of protein complexes that we studied in mice in other species, especially in humans. We believe that evolutionary studies will be a way to work out the important proteins for higher cognitive functions and we hope to describe the human synapse composition for the first time. Neurobiology is a very important field of science and it will be much more for the years to come. A deep comprehension of the synapse will be essential to understand the brain performance, synapse biology is a nascent area of neurobiology in which Europe should invest to lead it.'