ANOPOPAGE

Population age structure and age structure modification via Wolbachia in Anopheles gambiae

Coordinatore	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD    more  Organization address address: University Offices, Wellington Square city: OXFORD postcode: OX1 2JD contact info Titolo: Prof. Nome: Stephen Cognome: Conway Email: send email Telefono: +44 1865 270043
Nazionalità Coordinatore	United Kingdom [UK]
Sito del progetto	http://cordis.europa.eu/projects/223241
Totale costo	1˙355˙286 €
EC contributo	1˙000˙000 €
Programma	FP7-HEALTH Specific Programme "Cooperation": Health
Code Call	FP7-HEALTH-2007-B
Funding Scheme	CP-FP
Anno di inizio	2009
Periodo (anno-mese-giorno)	2009-02-01   -   2012-07-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD  Organization address address: University Offices, Wellington Square city: OXFORD postcode: OX1 2JD contact info Titolo: Prof. Nome: Stephen Cognome: Conway Email: send email Telefono: +44 1865 270043	UK (OXFORD)	coordinator	540˙203.80
2	CENTRE NATIONAL DE RECHERCHE SCIENTIFIQUE ET TECHNOLOGIQUE*INSTITUT DE RECHERCHE EN SCIENCES DE LA SANTE  Organization address address: B P 7047 city: OUAGADOUGOU postcode: 3 contact info Titolo: Mr. Nome: Levy Cognome: Kaboré Email: send email Telefono: +226 20 974868 Fax: +226 20 974868	BF (OUAGADOUGOU)	participant	183˙512.00
3	ARISTOTELIO PANEPISTIMIO THESSALONIKIS  Organization address address: Administration Building, University Campus city: THESSALONIKI postcode: 54124 contact info Titolo: Ms. Nome: Christina Cognome: Besta Email: send email Telefono: +30 2310 996745 Fax: +30 2310 853283	EL (THESSALONIKI)	participant	165˙600.00
4	International Centre of Insect Physiology and Ecology  Organization address address: "Off Thika Road, Duduville Campus" city: Nairobi postcode: 100 contact info Titolo: Mr. Nome: Roger Cognome: Finan Email: send email Telefono: +254 20 8561171 Fax: +254 20 8632001	KE (Nairobi)	participant	57˙928.16
5	INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT  Organization address address: Boulevard de Dunkerque - CS 90009 44 city: MARSEILLE postcode: 13572 contact info Titolo: Ms. Nome: Ariel Cognome: Crozon Email: send email Telefono: 33148037721 Fax: 33140362385	FR (MARSEILLE)	participant	52˙756.00
6	THE UNIVERSITY OF QUEENSLAND  Organization address address: ST LUCIA city: BRISBANE postcode: 4072 contact info Titolo: Ms. Nome: Nicole Cognome: Thompson Email: send email Telefono: 61733653560 Fax: 61733654455	AU (BRISBANE)	participant	0.00

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 Obiettivo del progetto (Objective)

'One of the most critical factors contributing to the vectorial capacity of malaria vector mosquitoes is the mean age attained by adult females, because after picking up the Plasmodium parasite there is a lengthy incubation period before transmission can occur. A virulent strain of the endosymbiotic bacterium Wolbachia called wMelPop reduces adult lifespan in its native Drosophila host, and has recently been shown to do the same following transfer into Aedes mosquitoes. We will examine its potential as a novel malaria control tool by creating and characterizing Anopheles cell lines containing wMelPop, and purifying and transferring it into An. gambiae by microinjection. We will then characterize the cytoplasmic incompatibility phenotype by which Wolbachia spreads itself, virulence (lifespan shortening effects), maternal transmission rates, and tissue distribution of introduced Wolbachia, together with analyses of mosquito gene expression using microarrays. Development of a molecular age estimation assay for the An. gambiae complex will be undertaken by adapting a new quantitative RT-PCR method for use in An. gambiae. We will then set up a greenhouse population of a member of the An. gambiae complex in Kenya that is viable over multiple generations, release marked mosquitoes to calibrate the molecular age estimation assays under semi-field conditions, and compare age structure between greenhouse and wild populations. In Burkina Faso we will estimate population age structure in the An. gambiae complex at 3 field sites, in different seasons and with / without insecticide treated net use. Liaison will take place with government institutions and local communities on regulatory issues and desirability of future Wolbachia-based trials in both countries. We will also build a suite of mathematical models to allow the analysis of different interventions that affect adult mosquito longevity, and incorporate the dynamics of Wolbachia spread in an age-structured population.'