SENSOMETAL

Nanosensors to monitor metal dynamics in living plant cells

Coordinatore	CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE    more  Organization address address: Rue Michel -Ange 3 city: PARIS postcode: 75794 contact info Titolo: Dr. Nome: Michèle Cognome: Saumon Email: send email Telefono: +33 1 69823272 Fax: +33 1 69823333
Nazionalità Coordinatore	France [FR]
Totale costo	230˙963 €
EC contributo	230˙963 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2007-4-1-IOF
Funding Scheme	MC-IOF
Anno di inizio	2009
Periodo (anno-mese-giorno)	2009-02-01   -   2012-08-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE  Organization address address: Rue Michel -Ange 3 city: PARIS postcode: 75794 contact info Titolo: Dr. Nome: Michèle Cognome: Saumon Email: send email Telefono: +33 1 69823272 Fax: +33 1 69823333	FR (PARIS)	coordinator	0.00

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 Obiettivo del progetto (Objective)

'Metals, such as manganese or zinc, are vital elements for plant growth and development. They are involved in many biological processes and one third of characterized enzymes are metalloproteins. Because metal excess or metal deprivation is deleterious for cells, plants have developed mechanisms to regulate the uptake, the transport and the storage of metals. Dr Thomine’s group, in Gif-sur-Yvette (France), has obtained evidence that metal compartmentalization is essential for metal homeostasis. However, no tools are currently available to monitor the dynamics of metal concentrations in living plants. Prof Frommer’s group, in Stanford (USA), pioneered the design of genetically encodable FRET nanosensors for living cells. The project will aim at developing a set of metal nanosensors to image in vivo the dynamics of manganese and zinc localization and their regulation in Arabidopsis thaliana. An integrated approach in plants, combining the use of mutants impaired in metal transport and metal imaging, will enable us to further understand biological processes underlying the control of metal homeostasis in plants. This project will enable the researcher to acquire new expertise in the design of nanosensors for living cells.'

Introduzione (Teaser)

Fluorescent sensors are the best tools for monitoring the dynamics of metals in living cells. The main aim of an EU-funded project was to apply the sensors to monitor the in vivo dynamics of transient metals in plant cells.