BIOSCENT
"BIOactive highly porous and injectable Scaffolds controlling stem cell recruitment, proliferation and differentiation and enabling angiogenesis for Cardiovascular ENgineered Tissues"
| Coordinatore | UNIVERSITA DI PISA
Organization address
address: Lungarno Pacinotti 43/44 contact info |
| Nazionalità Coordinatore | Italy [IT] |
| Sito del progetto | http://inspiralia-delivery.eu/fp7bioscent_eu/ |
| Totale costo | 8˙339˙349 € |
| EC contributo | 6˙305˙731 € |
| Programma | FP7-NMP
Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies |
| Code Call | FP7-NMP-2007-LARGE-1 |
| Funding Scheme | CP-IP |
| Anno di inizio | 2009 |
| Periodo (anno-mese-giorno) | 2009-01-01 - 2013-12-31 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
UNIVERSITA DI PISA
Organization address
address: Lungarno Pacinotti 43/44 contact info |
IT (PISA) | coordinator | 1˙157˙800.00 |
| 2 |
MEDIZINISCHE HOCHSCHULE HANNOVER
Organization address
address: Carl-Neuberg-Strasse 1 contact info |
DE (HANNOVER) | participant | 772˙480.00 |
| 3 |
PERA INNOVATION LIMITED
Organization address
address: Innovation Park, Nottingham Road contact info |
UK (MELTON MOWBRAY, LEICESTERSHIRE) | participant | 752˙800.00 |
| 4 |
UNIVERSITA DEGLI STUDI DI PARMA
Organization address
address: VIA UNIVERSITA 12 contact info |
IT (PARMA) | participant | 555˙800.00 |
| 5 |
SORIN BIOMEDICA CARDIO S.R.L.
Organization address
address: VIA BENIGNO CRESPI 17 contact info |
IT (MILANO) | participant | 498˙600.00 |
| 6 |
THE UNIVERSITY OF MANCHESTER
Organization address
address: OXFORD ROAD contact info |
UK (MANCHESTER) | participant | 392˙200.00 |
| 7 |
FRIEDRICH-ALEXANDER-UNIVERSITAT ERLANGEN NURNBERG
Organization address
address: SCHLOSSPLATZ 4 contact info |
DE (ERLANGEN) | participant | 386˙090.44 |
| 8 |
GmbH IBT - IMMUNOLOGICAL AND BIOCHEMICALTESTSYSTEMS GMBH*
Organization address
address: Aspenhaustrasse 25 contact info |
DE (Reutlingen) | participant | 261˙600.00 |
| 9 |
TECNOLOGIAS AVANZADAS INSPIRALIA SL
Organization address
address: CALLE MIGUEL VILLANUEVA 2 6 PISO PUERTA 3 contact info |
ES (LOGRONO) | participant | 251˙167.00 |
| 10 |
POLITECNICO DI TORINO
Organization address
address: Corso Duca degli Abruzzi 24 contact info |
IT (TORINO) | participant | 219˙930.00 |
| 11 |
KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW
Organization address
address: KLOVENIERSBURGWAL 29 HET TRIPPENHUIS contact info |
NL (AMSTERDAM) | participant | 205˙680.00 |
| 12 |
Cambridge Research Biochemicals
Organization address
address: "Belasis Court, Belasis Hall Technology Park 10" contact info |
UK (Billingham) | participant | 196˙400.00 |
| 13 |
Chempilots a/s
Organization address
address: Rugmarken 24-26 contact info |
DK (FARUM) | participant | 179˙600.00 |
| 14 |
INSTITUTUL DE CHIMIE MACROMOLECULARA PETRU PONI
Organization address
address: Aleea Grigore Ghica Voda 41A contact info |
RO (IASI) | participant | 161˙200.00 |
| 15 |
USTAV EXPERIMENTALNI MEDICINY AKADEMIE VED CESKE REPUBLIKY VEREJNA VYZKUMNA INSTITUCE
Organization address
address: VIDENSKA 1083 contact info |
CZ (PRAHA 4) | participant | 159˙760.00 |
| 16 |
IMM RECHERCHE SAS
Organization address
address: BOULEVARD JOURDAN 42 contact info |
FR (PARIS) | participant | 152˙354.00 |
| 17 |
IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE
Organization address
address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD contact info |
UK (LONDON) | participant | 2˙269.56 |
| 18 |
SORIN GROUP ITALIA SRL
Organization address
address: Via Benigno Crespi 17 contact info |
IT (Milano) | participant | 0.00 |
Mappa
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Obiettivo del progetto (Objective)
'Congenital and acquired diseases of the heart are the leading causes of morbidity and mortality in the world today; 7.2 million people die each year due to coronary heart disease, being the first cause of mortality in population above 60 years old, and the second cause after HIV in world wide young population. There is an urgent demand for new methods to repair and replace damaged cardiovascular tissues. One of the most promising ways to achieve this goal is the development of regenerative therapies aided with novel intelligent nanobiomaterials such as bioactive scaffolds. The overall objective of this project is the development of innovative bioactive polymeric scaffolds able to guide tissue formation from dissociated stem cells, for engineering autologous cardiovascular replacements, namely vascular tissues, heart valves and cardiac muscle. Two different strategies will be followed to approach creating new engineered tissue: 1.In vitro tissue engineering: according to the most frequent tissue engineering paradigm, cells will be seeded on a scaffold composed of synthetic polymer or natural material and the tissue will be matured in vitro in a bioreactor, in order to obtain a construct that can be implanted in the appropriate anatomic location as a prosthesis; 2.In vivo tissue engineering: unseeded scaffolds that attract endogenous cells and control cell proliferation and differentiation will be implanted to repopulate and remodel an altered cardiovascular tissue. The strong innovative content of the project is in the realisation of multifunctional scaffolds which can guide complex cellular processes such as adhesion, proliferation and differentiation, processes fundamental for tissue regeneration. It is therefore necessary to design integrated material scaffolds and culture environments, which can appropriately confer biochemical, morphological, electrical and mechanical stimuli to a developing tissue.'
Introduzione (Teaser)
Cardiovascular diseases such as myocardial infarction and stroke account for nearly half of the deaths in developed countries. A European consortium is proposing a new treatment for cardiac tissue repair through implantation of specialised scaffolds carrying stem cells.
Altri progetti dello stesso programma (FP7-NMP)
REDONTAP (2010)
Proposal for the Continuous Proliferation & Simultaneous Maturation of Haematopoietic Stem Cells into Blood Cell Lineages
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