ENDASYM

Asymmetric endosomes in asymmetric cell division and tumorigenesis

Coordinatore	UNIVERSITE DE GENEVE    more  Organization address address: Rue du General Dufour 24 city: GENEVE postcode: 1211 contact info Titolo: Prof. Nome: Marcos Cognome: Gonzalez-Gaitan Email: send email Telefono: +41 22 379 64 61 Fax: +41.22.37.96470
Nazionalità Coordinatore	Switzerland [CH]
Totale costo	0 €
EC contributo	180˙234 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-IEF-2008
Funding Scheme	MC-IEF
Anno di inizio	2009
Periodo (anno-mese-giorno)	2009-06-01   -   2011-05-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	UNIVERSITE DE GENEVE  Organization address address: Rue du General Dufour 24 city: GENEVE postcode: 1211 contact info Titolo: Prof. Nome: Marcos Cognome: Gonzalez-Gaitan Email: send email Telefono: +41 22 379 64 61 Fax: +41.22.37.96470	CH (GENEVE)	coordinator	180˙234.44

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 Obiettivo del progetto (Objective)

'Recent Drosophila reports show that directional Notch signalling during asymmetric cell division is mediated by asymmetric endocytic trafficking. Unpublished data from the host lab showed that directional Notch signalling is initiated by the directed targeting towards the signal-receiving cell of specific endocytic compartments, the Sara endosomes, which carry the receptor Notch and its ligand Delta. I will combine automated quantitative analysis of the movement of these endosomes with an RNAi screen to identify cytoskeletal elements controlling Sara/Notch/Delta endosome dynamics. In vitro reconstitution of endosomal trafficking and biophysical micro-manipulation of these endosomes will unravel the fine molecular role of the machineries discovered in the screen. I will then study asymmetric endosomal dynamics in the stem cells of the fly brain in wild-type and tumorigenic conditions. The ultimate goal is to uncover the relation between endosomal dynamics, stem cell self-renewal and brain tumorigenesis.'