HIIS

The humoral innate immune system: long pentraxins as a paradigm

Coordinatore	HUMANITAS MIRASOLE SPA    more Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.
Nazionalità Coordinatore	Italy [IT]
Totale costo	2˙066˙200 €
EC contributo	2˙066˙200 €
Programma	FP7-IDEAS-ERC Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	ERC-2008-AdG
Funding Scheme	ERC-AG
Anno di inizio	2009
Periodo (anno-mese-giorno)	2009-06-01   -   2014-05-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	HUMANITAS MIRASOLE SPA  Organization address address: "Via Manzoni, 56" city: ROZZANO-MILAN postcode: 20089 contact info Titolo: Dr. Nome: Danilo Cognome: Petroni Email: send email Telefono: +39 2 82242435 Fax: +39 2 82245191	IT (ROZZANO-MILAN)	hostInstitution	2˙066˙200.00
2	HUMANITAS MIRASOLE SPA  Organization address address: "Via Manzoni, 56" city: ROZZANO-MILAN postcode: 20089 contact info Titolo: Prof. Nome: Alberto Cognome: Mantovani Email: send email Telefono: +39 2 82242444 Fax: +39 2 82245101	IT (ROZZANO-MILAN)	hostInstitution	2˙066˙200.00

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 Obiettivo del progetto (Objective)

'The innate immune system consists of humoral and a cellular arm, but attention has largely been focused on cells and their receptors. The humoral innate immune system (HIIS) is generally represented as a collection of diverse molecules (collectins, ficolins, pentraxins). A tenet underlying this application is that in spite of molecular diversity, the HIIS is built on general principles and logic conserved in evolution. This general view will be put to a test capitalizing on the discovery by the applicant of the long pentraxin family, the prototype of which is PTX3. PTX3 is a multifunctional fluid phase pattern recognition receptor, highly conserved in evolution, at the interface between innate immunity/ inflammation and female fertility /matrix remodelling. The specific aims of the studies outlined herein are: 1) better define the repertoire of HIIS receptors by identifying new receptor(s) (eg PTX4) and ligands as well as interaction among receptor families (eg Ficolins); 2) pursue the structure and function of PTX3 as well as of newly discovered related molecules; 3) using genetic and cellular approaches define the relative importance of different cellular sources (eg lymphatic tissue); 4) based on 1-3, address fundamental mechanisms and logic in the interplay between cellular and humoral innate immunity; 5) explore the applicative potential of long pentraxins as diagnostics; 6) based on 1), engineer new pentraxins as potential therapeutics. The focus will largely be on unexpected turns, based on preliminary results, including: coupling of members belonging to different molecular classes; mechanisms of regulation of innate immunity (pathways of complement activation; P-selectin and leukocyte trafficking); the role in the extracellular matrix of lymphatic vessels.'