BIOMIMETIC-CORTEX

"Actin-membrane interaction in biomimetic and living cellular systems studied with a novel, high precision optical method."

Coordinatore	INSTITUT CURIE    more  Organization address address: 26, rue d'Ulm city: PARIS postcode: 75248 contact info Titolo: Dr. Nome: Cécile Cognome: Sykes Email: send email Telefono: ++33 (0)1 42 34 67 90 Fax: ++33 (0)1 40 51 06 36
Nazionalità Coordinatore	France [FR]
Totale costo	171˙033 €
EC contributo	171˙033 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2007-2-1-IEF
Funding Scheme	MC-IEF
Anno di inizio	2009
Periodo (anno-mese-giorno)	2009-10-01   -   2011-03-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	INSTITUT CURIE  Organization address address: 26, rue d'Ulm city: PARIS postcode: 75248 contact info Titolo: Dr. Nome: Cécile Cognome: Sykes Email: send email Telefono: ++33 (0)1 42 34 67 90 Fax: ++33 (0)1 40 51 06 36	FR (PARIS)	coordinator	0.00

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 Obiettivo del progetto (Objective)

'The lethal potential of cancer is due to abnormal cell division and aggressive metastatic activity that turn resting cancer cells into motile structures which spread through an organism, resulting in numerous and often uncontrollably growing subpopulations. It is well known that both cell motility and cell division depend crucially on cell mechanics, namely on actin cortex. The actin cortex consists of a dense biopolymer network, steadily contracted by myosin motors. A key to understanding the abnormal motility and proliferation of cancer cells is the investigation and quantification of the physical properties of the actin cortex. Of special interest is the activity of the acto-myosin network and its interaction with the plasma membrane. This actin-membrane interplay is a major contributor to many physical properties of the whole cell. We propose a systematic study of acto-myosin membrane interactions using biomimetic and living cells in combination with a novel optical method that allows simultaneous manipulation and detection of the cell edge with high spatial and temporal resolution. Our main objectives are: a) to quantify the physics of the actin cortex in biomimetic cells; b) to understand the nonequilibrium statistical mechanics of active acto-myosin networks; c) to study of actin-membrane interactions in the cell cortex and the lamellipodium of living cells. The applicant and the host institute provide complementary skills for this project. The applicant has expertise in advanced optical detection methods, cell motility and stochastic processes, and the host institute will provide the biomimetic actin cortex system, expertise on biomimetics, active systems and biology and the interdisciplinary working environment, including biologists and biochemists, necessary for this project. In this respect both the applicant and the host institution will benefit from the fellowship.'