MATVIR

Mathematical Virology: A classification of virus architecture and the structural transitions important for maturation and infection

Coordinatore	UNIVERSITY OF YORK    more  Organization address address: HESLINGTON city: YORK NORTH YORKSHIRE postcode: YO10 5DD contact info Titolo: Mr. Nome: David Cognome: Hudson Email: send email Telefono: +44(0)1904 434419 Fax: +44(0)1904-434119
Nazionalità Coordinatore	United Kingdom [UK]
Totale costo	166˙040 €
EC contributo	166˙040 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2009-IEF
Funding Scheme	MC-IEF
Anno di inizio	2010
Periodo (anno-mese-giorno)	2010-05-01   -   2012-04-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	UNIVERSITY OF YORK  Organization address address: HESLINGTON city: YORK NORTH YORKSHIRE postcode: YO10 5DD contact info Titolo: Mr. Nome: David Cognome: Hudson Email: send email Telefono: +44(0)1904 434419 Fax: +44(0)1904-434119	UK (YORK NORTH YORKSHIRE)	coordinator	166˙040.80

Mappa

 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

 Obiettivo del progetto (Objective)

'This project in Mathematical Biology addresses two important questions concerning the structure and life cycle of viruses: -) The classification of the possible three-dimensional shapes of the capsid proteins compatible with icosahedral symmetry (the most common symmetry of viral capsids) by means of group theory and tiling theory; -) The modeling and prediction of the structural transitions of the viral capsids (protein containers encapsidating the genome) involved in the maturation of the viral particles, using ideas and techniques of the mathematical theory of phase transitions in crystals. The expected results will clarify, on a geometrical basis, the spectrum of structural features that can occur in the viral capsids with icosahedral symmetry (such as the shape and the bonds between the proteins) and elucidate the mechanisms essential for their maturation and infectivity. Such insights have relevant implications for the design of antiviral drugs that inhibit the assembly or the maturation of viral capsids, and the manufacture of self-assembling virus-like containers for drug delivery.'