TACIT

Targeted Amphoteric Carriers in ImmunoTherapy

Coordinatore	"BIOMEDICAL RESEARCH FOUNDATION, ACADEMY OF ATHENS"    more  Organization address address: Soranou Efesiou 4 city: ATHENS postcode: 11527 contact info Titolo: Mr. Nome: Dimitris Cognome: Raptis Email: send email Telefono: +30 210 6597574 Fax: +30 210 6597571
Nazionalità Coordinatore	Greece [EL]
Totale costo	960˙985 €
EC contributo	960˙985 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-IAPP-2008
Funding Scheme	MC-IAPP
Anno di inizio	2009
Periodo (anno-mese-giorno)	2009-08-01   -   2013-07-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	"BIOMEDICAL RESEARCH FOUNDATION, ACADEMY OF ATHENS"  Organization address address: Soranou Efesiou 4 city: ATHENS postcode: 11527 contact info Titolo: Mr. Nome: Dimitris Cognome: Raptis Email: send email Telefono: +30 210 6597574 Fax: +30 210 6597571	EL (ATHENS)	coordinator	326˙604.00
2	CENIX BIOSCIENCE GMBH  Organization address address: TATZBERG 47 city: DRESDEN postcode: 1307 contact info Titolo: Dr. Nome: Karen Cognome: Huppertz Email: send email Telefono: 493514000000	DE (DRESDEN)	participant	411˙104.00
3	PANEPISTIMIO KRITIS  Organization address address: UNIVERSITY CAMPUS GALLOS city: RETHIMNO postcode: 74100 contact info Titolo: Dr. Nome: Christos Cognome: Tsatsanis Email: send email Telefono: 302810000000 Fax: 302810000000	EL (RETHIMNO)	participant	209˙023.00
4	NOVOSOM AG  Organization address address: Weinbergweg 22 city: HALLE postcode: 6120 contact info Titolo: Mr. Nome: Sebastian Cognome: Kehres Email: send email Telefono: 493456000000 Fax: 493456000000	DE (HALLE)	participant	14˙254.00

Mappa

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 Obiettivo del progetto (Objective)

'The past year has been exciting for oligonucleotide-based drug discovery and development. The Nobel Prize was awarded to Mello and Fire for discovering RNA interference. There was also big investment from the Pharmaceutical industry to Biotechnology companies-pioneers in oligonucleotide therapeutics such as Sirna, Alnylam and Isis, all US-based. High expectations were therefore raised but further progress is hampered by the issue of systemic delivery; siRNA oligonucleotides are ineffective in vivo whereas antisense DNA oligonucleotides can be effective for liver-specific targets only. Therefore, delivery systems are a matter of intense investigation with the most recent advances being cationic liposomes with PEGylation or diffusible PEGylation. However, these carriers face tolerability issues, non-specific immune stimulation or limited biodistribution. Novosom has developed a completely novel carrier system based on amphoteric liposomes. This incorporates structural features with unique charge-reversal properties which result into safety and performance advantages over the current best alternative carriers. The aim of this Consortium is to built on Novosom’s carrier technology to develop novel improved amphoteric liposomes with targeted delivery modalities to cells of the immune system, and to apply them for therapeutic oligonucleotide delivery to inflammatory diseases. Knowledge transfer between partners will facilitate the design of novel carriers, identification of targets and validation using in vivo models of inflammatory disease. The Consortium stems from two very successful one-to-one collaborations and proposes here a fully integrated program of translational, interdisciplinary research. Knowledge transfer between Novosom, a European leader in oligonucleotide delivery technologies, and two Academic Institutions of international standing in inflammatory disease therapeutics provides the competitiveness needed for a European team in this US-dominated field.'

Introduzione (Teaser)

Therapeutics based on genetics promise solutions for devastating illnesses that cannot be treated by conventional approaches. Development of gene carriers are necessary for specific, efficient and safe treatment.