AGING_HORMONE

The reward system in healthy ageing and its modulation by gonadal steroid hormones: multimodal neuroimaging studies (fMRI/PET)

Coordinatore	THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN    more  Organization address address: College Green - city: DUBLIN postcode: 2 contact info Titolo: Ms. Nome: Deirdre Cognome: Savage Email: send email Telefono: +353 1 8961942 Fax: +353 1 7071633
Nazionalità Coordinatore	Ireland [IE]
Totale costo	245˙450 €
EC contributo	245˙450 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-IEF-2008
Funding Scheme	MC-IEF
Anno di inizio	2009
Periodo (anno-mese-giorno)	2009-05-01   -   2011-04-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN  Organization address address: College Green - city: DUBLIN postcode: 2 contact info Titolo: Ms. Nome: Deirdre Cognome: Savage Email: send email Telefono: +353 1 8961942 Fax: +353 1 7071633	IE (DUBLIN)	coordinator	245˙450.81

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 Obiettivo del progetto (Objective)

'Reward processing plays a fundamental role in motivation, learning and cognition. Using fMRI in humans, we recently identified the neural structures involved when anticipating uncertain rewards. Cognitive impairments and dysfunction of the dopaminergic system are observed in healthy aging and in several neurological and psychiatric disorders. Moreover, damage from stroke and neurodegeneration in dementia may be retarded by estrogen and estrogens may prevent the deleterious effects of aging on cognition when administered soon after the cessation of ovarian function. However little is known about the effects of ageing and hormone replacement therapy (HRT) on the reward system and dopamine synthesis. The goals of this research program are to investigate the role of ageing in men and women and the effect of age-related hormonal decline in post-menopausal women with and without hormone replacement therapy on activation of the reward system and on dopaminergic. Using both fMRI and fDOPA PET, we shall investigate: 1) the activation of the reward system with fMRI in our monetary reward task; 2) dopamine synthesis in the midbrain and the striatum using F-DOPA PET; 3) the relationships between activation of the reward system and the levels of midbrain/striatum dopamine synthesis by combining fMRI and F-DOPA PET results in the same individuals; 4) the effect of HRT on the reward system and the dopaminergic function in post-menopausal women. Our findings should clarify the relationships between activation of the reward system, dopamine synthesis and the effect of ageing and HRT.'

Introduzione (Teaser)

Reward processing plays a fundamental role in motivation, learning and cognition. European scientists looked into how the reward pathway is affected by sex hormones and gets altered during ageing.