NRLIOD

Novel Receptor:Ligand Interactions in Osteolytic Diseases

Coordinatore	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE    more  Organization address address: The Old Schools, Trinity Lane city: CAMBRIDGE postcode: CB2 1TN contact info Titolo: Ms. Nome: Edna Cognome: Murphy Email: send email Telefono: +44 1223 333543 Fax: +44 1223 332988
Nazionalità Coordinatore	United Kingdom [UK]
Totale costo	338˙737 €
EC contributo	338˙737 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-IOF-2008
Funding Scheme	MC-IOF
Anno di inizio	2009
Periodo (anno-mese-giorno)	2009-06-01   -   2012-05-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE  Organization address address: The Old Schools, Trinity Lane city: CAMBRIDGE postcode: CB2 1TN contact info Titolo: Ms. Nome: Edna Cognome: Murphy Email: send email Telefono: +44 1223 333543 Fax: +44 1223 332988	UK (CAMBRIDGE)	coordinator	338˙737.62

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 Obiettivo del progetto (Objective)

'Pathological bone loss (osteolysis), the process whereby osteoclasts erode mineralised bone matrix, remains an unresolved challenge in the pathology of osteolytic diseases, such as osteoporosis, rheumatoid arthritis (RA) and osteolytic bone cancers. Identification of the receptors involved in osteoclast development (osteoclastogenesis) is currently a high priority in osteoclast research. The goal of this research is to identify and understand the receptors and ligands regulating osteoclastogenesis. The primary aim of this proposal is to identify how these osteoclastogenic signals operate in osteolytic diseases. OSCAR is an osteoclast receptor that delivers potent osteoclastogenic signals. I have discovered that type I-IV collagens (major structural proteins at sites of diseased joint and bone erosion) are ligands for OSCAR and drive osteoclastogenesis. This exciting new finding has changed our understanding of the environmental signals regulating osteoclastogenesis. I will use gene knockouts, mouse and human disease models to dissect the molecular interactions required for osteoclastogenesis using OSCAR as a model receptor/ligand interaction. Using these techniques, I will determine the role of the OSCAR, and other receptors, in osteoclastogenesis in vivo and in the diseased state.'