OSCHSCAF

Development of new strategies for osteochondral regeneration

Coordinatore	UNIVERSITY OF KEELE    more  Organization address address: KEELE UNIVERSITY FINANCE DPT city: KEELE postcode: ST5 5BG contact info Titolo: Dr. Nome: Ying Cognome: Yang Email: send email Telefono: 441783000000 Fax: 441783000000
Nazionalità Coordinatore	United Kingdom [UK]
Totale costo	0 €
EC contributo	131˙594 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-IEF-2008
Funding Scheme	MC-IEF
Anno di inizio	2009
Periodo (anno-mese-giorno)	2009-08-01   -   2011-01-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	UNIVERSITY OF KEELE  Organization address address: KEELE UNIVERSITY FINANCE DPT city: KEELE postcode: ST5 5BG contact info Titolo: Dr. Nome: Ying Cognome: Yang Email: send email Telefono: 441783000000 Fax: 441783000000	UK (KEELE)	coordinator	131˙594.02

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 Obiettivo del progetto (Objective)

'In contrast to any conventional therapies, regeneration medicine such as tissue engineering requires highly cross-disciplinary knowledge and technology. In this proposal, we propose new strategies for tissue engineering osteochondral tissue to tackle a disease caused by physical trauma and age-related degeneration, a major health problem in western societies. Despite various therapeutic options, no optimal solution has been found for the treatment of cartilage and osteochondral defects. This project aims to develop a new type of osteochondral scaffold to stimulate chondrocytes and osteoblasts growing in a monolithic structure with different architecture regions. The frame of the scaffold will be constructed by degradable PLA/PCL blends with tailorable degradation mechanisms. The collage II and hyaluronan gel will be incorporated into the large pore region by plastic compression to enhance chondrogenesis, whilst HA and TRAP signalling components will be adhered to small pore region to promote bone formation. To accelerate the maturation of the tissue and matrix production, external mechanical stimulation to the constructs will be applied. The feature of the various pore architecture through the scaffold enables transfer of differentiated strain to the seeded cells depending on the area where the cells are present under a single load regime. This multidisciplinary project will be hosted by one of EU excellent institute within NoE network in tissue engineering. The research fellow has accepted comprehensive training in materials science in a top ranked university in Turkey. The complementary expertise and experience between the fellow and the host ensure the success of the proposal. The success of the project shall share the knowledge and technology between the fellow and the host and enhance the fellow’s career development.'