SYBARIS
Finding biomarkers of anti-microbial drug resistance via a systems biology analysis of fungal pathogen interactions with the human immune system
| Coordinatore | EUROPEAN MOLECULAR BIOLOGY LABORATORY
Organization address
address: Meyerhofstrasse 1 contact info |
| Nazionalità Coordinatore | Germany [DE] |
| Totale costo | 5˙672˙482 € |
| EC contributo | 4˙291˙161 € |
| Programma | FP7-HEALTH
Specific Programme "Cooperation": Health |
| Code Call | FP7-HEALTH-2009-single-stage |
| Funding Scheme | CP-FP |
| Anno di inizio | 2009 |
| Periodo (anno-mese-giorno) | 2009-11-01 - 2013-04-30 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
EUROPEAN MOLECULAR BIOLOGY LABORATORY
Organization address
address: Meyerhofstrasse 1 contact info |
DE (HEIDELBERG) | coordinator | 867˙883.00 |
| 2 |
FUNDACIO PRIVADA PARC CIENTIFIC DE BARCELONA
Organization address
address: Baldiri i Reixac, 10-12 contact info |
ES (BARCELONA) | participant | 1˙217˙463.00 |
| 3 |
THE UNIVERSITY OF MANCHESTER
Organization address
address: OXFORD ROAD contact info |
UK (MANCHESTER) | participant | 591˙716.40 |
| 4 |
ALERGENETICA SL
Organization address
address: "CALDERON DE LA BARCA 5, 5, #27" contact info |
ES (SANTA CRUZ DE TENERIFE) | participant | 486˙000.00 |
| 5 |
UNIVERSITA DEGLI STUDI DI FIRENZE
Organization address
address: Piazza San Marco 4 contact info |
IT (Florence) | participant | 336˙800.00 |
| 6 |
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Organization address
address: Rue Michel -Ange 3 contact info |
FR (PARIS) | participant | 299˙842.00 |
| 7 |
UNIVERSIDADE DE AVEIRO
Organization address
address: CAMPO UNIVERSITARIO DE SANTIAGO contact info |
PT (AVEIRO) | participant | 291˙457.00 |
| 8 |
UNIVERSITA DEGLI STUDI DI PERUGIA
Organization address
address: PIAZZA DELL' UNIVERSITA 1 contact info |
IT (PERUGIA) | participant | 200˙000.00 |
| 9 |
COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
Organization address
address: RUE LEBLANC 25 contact info |
FR (PARIS 15) | participant | 0.00 |
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Obiettivo del progetto (Objective)
'We propose a systems biology study of the specificity of response of the cell-mediated immune system to fungal microorganisms in order to investigate the genetic basis of susceptibility to fungal disease and elucidate molecular mechanisms of drug resistance in fungal pathogens. An integrative approach, combining high-throughput and traditional wet-lab work with computational and bioinformatics methods, will be applied to identify biomarkers of resistance to currently available treatments and to develop novel putative drug target genes and pathways in different fungi. We will use Saccharomyces cerevisiae, a normally non-pathogenic yeast model organism, Candida albicans and Aspergillus fumigatus, two major recognized fungal pathogens as well as other Aspergillus spp. known to be multi-drug resistant and difficult to treat. This project meets the criteria of the call, the strategic objective of which is “to confront the increasing emergence and spread of antimicrobial drug resistant pathogens in Europe” by addressing a well-defined class of infectious disease caused by fungal pathogens, with significant morbidity and mortality in a large segment of the population, and a high economic cost due to resistance. The anticipated results are highly relevant to society in terms of reducing the burden of mortality and suffering in immunosuppressed patients and in terms of reducing medical costs associated with treating opportunistic fungal infections. The potential economic upside for novel broad-spectrum anti-infectives is very large. The worldwide market for antifungals is currently estimated at $4 billion US annually. We tackle the issues of anti-microbial drug resistance head on via a multidisciplinary systems biology study combining bacterial genetics, clinical and pharmacological research in a systems biology approach, integrating traditional wet-lab methods with those of functional genomics, proteomics, metabolomics and bioinformatics.'