VIRUS ENTRY

Molecular Mechanisms of Cell Entry of Enveloped Viruses

Coordinatore	HUMBOLDT-UNIVERSITAT ZU BERLIN    more  Organization address address: UNTER DEN LINDEN 6 city: BERLIN postcode: 10099 contact info Titolo: Mr. Nome: Ulrich Cognome: Winderl Email: send email Telefono: 493021000000 Fax: 493021000000
Nazionalità Coordinatore	Germany [DE]
Totale costo	3˙844˙983 €
EC contributo	3˙844˙983 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-ITN-2008
Funding Scheme	MC-ITN
Anno di inizio	2009
Periodo (anno-mese-giorno)	2009-10-01   -   2013-09-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	HUMBOLDT-UNIVERSITAT ZU BERLIN  Organization address address: UNTER DEN LINDEN 6 city: BERLIN postcode: 10099 contact info Titolo: Mr. Nome: Ulrich Cognome: Winderl Email: send email Telefono: 493021000000 Fax: 493021000000	DE (BERLIN)	coordinator	557˙486.00
2	UNIVERSITEIT UTRECHT  Organization address address: Heidelberglaan 8 city: UTRECHT postcode: 3584 CS contact info Titolo: Mr. Nome: Ricardo Cognome: Fernandez Email: send email Telefono: 31302532559 Fax: 31302532333	NL (UTRECHT)	participant	809˙040.00
3	EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZURICH  Organization address address: Raemistrasse 101 city: ZUERICH postcode: 8092 contact info Titolo: Prof. Nome: Ari Cognome: Helenius Email: send email Telefono: +41 44 632 68 17 Fax: +41 44 632 12 69	CH (ZUERICH)	participant	454˙486.00
4	TEL AVIV UNIVERSITY  Organization address address: RAMAT AVIV city: TEL AVIV postcode: 69978 contact info Titolo: Ms. Nome: Lea Cognome: Pais Email: send email Telefono: 97236408774 Fax: 97236409697	IL (TEL AVIV)	participant	424˙700.00
5	CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE  Organization address address: Rue Michel -Ange 3 city: PARIS postcode: 75794 contact info Titolo: Dr. Nome: Michèle Cognome: Saumon Email: send email Telefono: 33169823030 Fax: 33169823333	FR (PARIS)	participant	401˙904.00
6	FREIE UNIVERSITAET BERLIN  Organization address address: Kaiserswertherstrasse 16-18 city: BERLIN postcode: 14195 contact info Titolo: Dr. Nome: Michael Cognome: Veit Email: send email Telefono: 493021000000 Fax: 493021000000	DE (BERLIN)	participant	393˙807.00
7	INSTITUT PASTEUR  Organization address address: RUE DU DOCTEUR ROUX 25-28 city: PARIS CEDEX 15 postcode: 75724 contact info Titolo: Prof. Nome: Felix Cognome: Rey Email: send email Telefono: +33 1 45 68 85 63 Fax: +33 1 45 68 89 93	FR (PARIS CEDEX 15)	participant	364˙117.00
8	KAROLINSKA INSTITUTET  Organization address address: Nobels Vag 5 city: STOCKHOLM postcode: 17177 contact info Titolo: Mr. Nome: Ingwar Cognome: Lennerfors Email: send email Telefono: 4686089223 Fax: 4686089280	SE (STOCKHOLM)	participant	240˙341.00
9	Capsulution Pharma AG  Organization address address: VOLMERSTRASSE 7B city: Berlin postcode: 12489 contact info Titolo: Mr. Nome: Alexander Cognome: Herrmann Email: send email Telefono: +49 30 67069190 Fax: +49 30 67069101	DE (Berlin)	participant	199˙102.00

Mappa

 Word cloud

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 Obiettivo del progetto (Objective)

'Virus infections are a major cause of diseases and death among men and animals. The recent outbreak of SARS and the danger that an avian influenza virus may become pandemic, have clearly shown that members of any virus family can potentially turn into a pathogen. To combat virus infection and propagation, systematic and comprehensive studies both on viral components mediating virus-cell interactions, and on the cell biology behind virus entry are necessary. Our network, teaming academic and industrial groups, is aimed at undertaking an interdisciplinary effort to reveal the diversity of pathways and associated molecular mechanisms of cell entry of enveloped viruses. Research by experimental and theoretical approaches will be directed towards the identification of cellular receptors and of viral fusion proteins responsible for interaction with host cells. Among topics are folding, three-dimensional structure and conformational changes of viral fusion proteins as well as virus triggered signalling cascades in cells. Biophysical approaches will unravel the relationship between energetics of conformational changes of viral proteins and membrane bending and fusion. Together with industrial partners the project will identify potential targets for designed drug development, and will develop virus protein coated nanoparticles as new biotechnological and medical tools. The groups have complementary expertise at the highest standard in all required techniques of virology, molecular and cellular biology, biochemistry, proteomics, structural biology, theoretical and experimental biophysics. A challenging research and training environment in an international setting will provide young scientists with a network wide research-oriented training devoted to the specific aspects of virus entry and to structuring of industry projects and commercial exploitation of results, and a local training in soft skills and basic complementary education adapted to the personal needs.'

Introduzione (Teaser)

Understanding how different viruses mediate entry into a cell is central for designing antiviral strategies.