C7
"Cerebellar-Cortical Control: Cells, Circuits, Computation, and Clinic"
| Coordinatore | UNIVERSITY COLLEGE LONDON
Organization address
address: GOWER STREET contact info |
| Nazionalità Coordinatore | United Kingdom [UK] |
| Totale costo | 3˙662˙669 € |
| EC contributo | 3˙662˙669 € |
| Programma | FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) |
| Code Call | FP7-PEOPLE-ITN-2008 |
| Funding Scheme | MC-ITN |
| Anno di inizio | 2009 |
| Periodo (anno-mese-giorno) | 2009-11-01 - 2013-10-31 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
UNIVERSITY COLLEGE LONDON
Organization address
address: GOWER STREET contact info |
UK (LONDON) | coordinator | 772˙373.00 |
| 2 |
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Organization address
address: 's Gravendijkwal 230 contact info |
NL (ROTTERDAM) | participant | 427˙571.00 |
| 3 |
KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW
Organization address
address: KLOVENIERSBURGWAL 29 HET TRIPPENHUIS contact info |
NL (AMSTERDAM) | participant | 423˙150.00 |
| 4 |
THE UNIVERSITY OF BIRMINGHAM
Organization address
address: Edgbaston contact info |
UK (BIRMINGHAM) | participant | 415˙205.00 |
| 5 |
UNIVERSITAETSKLINIKUM ESSEN
Organization address
address: HUFELANDSTRASSE 55 contact info |
DE (ESSEN) | participant | 399˙526.00 |
| 6 |
EBERHARD KARLS UNIVERSITAET TUEBINGEN
Organization address
address: GESCHWISTER-SCHOLL-PLATZ contact info |
DE (TUEBINGEN) | participant | 394˙407.00 |
| 7 |
UNIVERSITEIT ANTWERPEN
Organization address
address: PRINSSTRAAT 13 contact info |
BE (ANTWERPEN) | participant | 394˙169.50 |
| 8 |
BEN-GURION UNIVERSITY OF THE NEGEV
Organization address
address: Office of the President - Main Campus contact info |
IL (BEER SHEVA) | participant | 341˙882.00 |
| 9 |
Alpha Omega Engineering Ltd.
Organization address
address: Ha Avoda 3 contact info |
IL (Nazareth Illit) | participant | 94˙386.00 |
Mappa
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Obiettivo del progetto (Objective)
'A functional understanding of the cerebellum, the structure of the human brain with the most neurons, requires the combined effort of scientists working from the cellular level up to the behavioural level, and it requires scientists trained to cross these levels. The C7 network brings together 9 research groups to form a European institute for the interdisciplinary study of the cerebellum. The network will provide a unique multi-disciplinary training experience for young researchers in systems neuroscience. We are joined by 5 industrial partners who will help to realize important technological innovations and the commercial potential by developing cutting-edge technology for research and clinical applications. With a combination of electrophysiology, behavioural and clinical research, computational modelling and neuroimaging we will aim to answer three important questions: a) What is the computation performed in cerebellar networks? We will provide a multi-level description of the basic cerebellar computational unit, the micro-column. b) How do distributed synaptic changes lead to learning? We link structure to function through an intense program of experimentation and modelling on the fast adaptation of motor behaviour thought by many to be the main function of the cerebellum. c) How do the closed loops between the cerebellum and neocortex generate motor control and cognition? Multi-site recordings, TMS and clinical studies will reveal the previously unexplored interaction between cerebellum and related structures. C7 includes two clinical research centres and two patient organizations, promoting the transfer of insights from basic science to clinical practice. In particular, we will explore brain compensation following cerebellar dysfunction using genetic mouse models and TMS. In sum, C7 will provide the interdisciplinary training environment necessary for a new understanding of the cerebellum.'
Introduzione (Teaser)
A European network of academia and industry set out to perform a multidisciplinary study of the cerebellum. The generated information brings us a step closer to comprehending the function of this complex organ.
Descrizione progetto (Article)
The cerebellum is the part of the brain that governs motor control and learning. Given that neuronal plasticity is central to the process of learning, understanding how plasticity forms in the cerebellum and how this part of the brain computes its signals could have important consequences for health and disease.
With EU funding, the 'Cerebellar-cortical control: Cells, circuits, computation, and clinic' (http://www.cerebellumc7.eu/ (C7)) project brought under the same umbrella leading experts in neuroscience to study cerebellar networks. During the project 17 young researchers were trained by the network participants in various aspects of neuroscience.
The key objectives were to delineate the neuronal activity in the cerebellum and understand how changes in neuronal synapses lead to learning. For this purpose, the consortium utilised electrophysiology, behavioural and clinical research, computational modelling and neuroimaging.
Researchers made significant technical advances in the recording of cerebellar neurons to study how the cerebellum exchanges information with the rest of the brain. This would allow prediction of behavioural phenotypes from neuronal activity in the cerebellum.
From a clinical perspective, they examined the neuronal events implicated in the rehabilitation of cerebellar patients and in degeneration. They also generated important insight into the mechanism of transcranial direct current stimulation, a method used to enhance learning. Additional roles of the cerebellum in learning the timing and order of sequential movements, and in language processing and prediction were investigated.
Through the training of the next generation of neuroscientists, the consortium worked to promote neuroscience and especially the study of the cerebellum.