C7

"Cerebellar-Cortical Control: Cells, Circuits, Computation, and Clinic"

Coordinatore	UNIVERSITY COLLEGE LONDON    more  Organization address address: GOWER STREET city: LONDON postcode: WC1E 6BT contact info Titolo: Dr. Nome: Joern Cognome: Diedrichsen Email: send email Telefono: +44 20 76791121 Fax: +44 78132835
Nazionalità Coordinatore	United Kingdom [UK]
Totale costo	3˙662˙669 €
EC contributo	3˙662˙669 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-ITN-2008
Funding Scheme	MC-ITN
Anno di inizio	2009
Periodo (anno-mese-giorno)	2009-11-01   -   2013-10-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	UNIVERSITY COLLEGE LONDON  Organization address address: GOWER STREET city: LONDON postcode: WC1E 6BT contact info Titolo: Dr. Nome: Joern Cognome: Diedrichsen Email: send email Telefono: +44 20 76791121 Fax: +44 78132835	UK (LONDON)	coordinator	772˙373.00
2	ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM  Organization address address: 's Gravendijkwal 230 city: ROTTERDAM postcode: 3015CE contact info Titolo: Prof. Nome: Maarten Anthonie Cognome: Frens Email: send email Telefono: +31 0107043561 Fax: +31 107044734	NL (ROTTERDAM)	participant	427˙571.00
3	KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW  Organization address address: KLOVENIERSBURGWAL 29 HET TRIPPENHUIS city: AMSTERDAM postcode: 1011 JV contact info Titolo: Prof. Nome: Christiaan Innocentius Cognome: De Zeeuw Email: send email Telefono: +31 20 5665500 Fax: +31 20 5666121	NL (AMSTERDAM)	participant	423˙150.00
4	THE UNIVERSITY OF BIRMINGHAM  Organization address address: Edgbaston city: BIRMINGHAM postcode: B15 2TT contact info Titolo: Prof. Nome: R Christopher Cognome: Miall Email: send email Telefono: +44 121 4142867 Fax: +44 121 4144897	UK (BIRMINGHAM)	participant	415˙205.00
5	UNIVERSITAETSKLINIKUM ESSEN  Organization address address: HUFELANDSTRASSE 55 city: ESSEN postcode: 45147 contact info Titolo: Prof. Nome: Dagmar Cognome: Timmann Email: send email Telefono: +49 201 723 3816 Fax: +49 201 723 5901	DE (ESSEN)	participant	399˙526.00
6	EBERHARD KARLS UNIVERSITAET TUEBINGEN  Organization address address: GESCHWISTER-SCHOLL-PLATZ city: TUEBINGEN postcode: 72074 contact info Titolo: Prof. Nome: Hans-Peter Cognome: Thier Email: send email Telefono: +49 7071 298 3057 Fax: +49 7071 29 5326	DE (TUEBINGEN)	participant	394˙407.00
7	UNIVERSITEIT ANTWERPEN  Organization address address: PRINSSTRAAT 13 city: ANTWERPEN postcode: 2000 contact info Titolo: Prof. Nome: Erik Cognome: De Schutter Email: send email Telefono: +32 3 820 26 16 Fax: +32 3 820 26 69	BE (ANTWERPEN)	participant	394˙169.50
8	BEN-GURION UNIVERSITY OF THE NEGEV  Organization address address: Office of the President - Main Campus city: BEER SHEVA postcode: 84105 contact info Titolo: Ms. Nome: Dori Cognome: Schneider Email: send email Telefono: +972 86472435 Fax: +972 86472930	IL (BEER SHEVA)	participant	341˙882.00
9	Alpha Omega Engineering Ltd.  Organization address address: Ha Avoda 3 city: Nazareth Illit postcode: 17105 contact info Titolo: Mr. Nome: Imad Cognome: Younis Email: send email Telefono: +972 46563327 Fax: +972 46574075	IL (Nazareth Illit)	participant	94˙386.00

Mappa

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 Obiettivo del progetto (Objective)

'A functional understanding of the cerebellum, the structure of the human brain with the most neurons, requires the combined effort of scientists working from the cellular level up to the behavioural level, and it requires scientists trained to cross these levels. The C7 network brings together 9 research groups to form a European institute for the interdisciplinary study of the cerebellum. The network will provide a unique multi-disciplinary training experience for young researchers in systems neuroscience. We are joined by 5 industrial partners who will help to realize important technological innovations and the commercial potential by developing cutting-edge technology for research and clinical applications. With a combination of electrophysiology, behavioural and clinical research, computational modelling and neuroimaging we will aim to answer three important questions: a) What is the computation performed in cerebellar networks? We will provide a multi-level description of the basic cerebellar computational unit, the micro-column. b) How do distributed synaptic changes lead to learning? We link structure to function through an intense program of experimentation and modelling on the fast adaptation of motor behaviour thought by many to be the main function of the cerebellum. c) How do the closed loops between the cerebellum and neocortex generate motor control and cognition? Multi-site recordings, TMS and clinical studies will reveal the previously unexplored interaction between cerebellum and related structures. C7 includes two clinical research centres and two patient organizations, promoting the transfer of insights from basic science to clinical practice. In particular, we will explore brain compensation following cerebellar dysfunction using genetic mouse models and TMS. In sum, C7 will provide the interdisciplinary training environment necessary for a new understanding of the cerebellum.'

Introduzione (Teaser)

A European network of academia and industry set out to perform a multidisciplinary study of the cerebellum. The generated information brings us a step closer to comprehending the function of this complex organ.

Descrizione progetto (Article)

The cerebellum is the part of the brain that governs motor control and learning. Given that neuronal plasticity is central to the process of learning, understanding how plasticity forms in the cerebellum and how this part of the brain computes its signals could have important consequences for health and disease.

With EU funding, the 'Cerebellar-cortical control: Cells, circuits, computation, and clinic' (http://www.cerebellumc7.eu/ (C7)) project brought under the same umbrella leading experts in neuroscience to study cerebellar networks. During the project 17 young researchers were trained by the network participants in various aspects of neuroscience.

The key objectives were to delineate the neuronal activity in the cerebellum and understand how changes in neuronal synapses lead to learning. For this purpose, the consortium utilised electrophysiology, behavioural and clinical research, computational modelling and neuroimaging.

Researchers made significant technical advances in the recording of cerebellar neurons to study how the cerebellum exchanges information with the rest of the brain. This would allow prediction of behavioural phenotypes from neuronal activity in the cerebellum.

From a clinical perspective, they examined the neuronal events implicated in the rehabilitation of cerebellar patients and in degeneration. They also generated important insight into the mechanism of transcranial direct current stimulation, a method used to enhance learning. Additional roles of the cerebellum in learning the timing and order of sequential movements, and in language processing and prediction were investigated.

Through the training of the next generation of neuroscientists, the consortium worked to promote neuroscience and especially the study of the cerebellum.