MODUCAT

New modular self-assembled homogeneous catalysts for asymmetric synthesis in water

Coordinatore	CONSIGLIO NAZIONALE DELLE RICERCHE    more  Organization address address: Piazzale Aldo Moro 7 city: ROMA postcode: 185 contact info Titolo: Dr. Nome: Maurizio Cognome: Peruzzini Email: send email Telefono: +39 055 5225280 Fax: +39 055 5225203
Nazionalità Coordinatore	Italy [IT]
Totale costo	163˙074 €
EC contributo	163˙074 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-IIF-2008
Funding Scheme	MC-IIF
Anno di inizio	2010
Periodo (anno-mese-giorno)	2010-02-17   -   2012-02-16

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	CONSIGLIO NAZIONALE DELLE RICERCHE  Organization address address: Piazzale Aldo Moro 7 city: ROMA postcode: 185 contact info Titolo: Dr. Nome: Maurizio Cognome: Peruzzini Email: send email Telefono: +39 055 5225280 Fax: +39 055 5225203	IT (ROMA)	coordinator	163˙074.44

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 Obiettivo del progetto (Objective)

'There is a continuous interest to apply homogeneous catalysis to asymmetric synthesis, which is the elective method for drugs production in pharmaceutical industry. Asymmetric catalysis provides the cheapest synthetic route to optically active compounds with minimal number of steps and reduced use of expensive chiral substrates. Replacing conventional methods with those involving asymmetric catalysis is then mandatory to reduce considerably energy/materials costs and the environmental impact of chemical manufacturing. The improvement of either efficiency and selectivity of traditional molecular chiral catalysts is a time consuming and expensive procedure that may be bypassed by the development of the innovative "modular catalysis" on which the MODUCAT proposal is concerning. The accomplishment of MODUCAT milestones will boost the application of asymmetric catalysts to several industrial processes. The main objectives of the project are: (1) to develop the modular assemblage of a chiral catalyst consisting of two independent units, separately responsible for activity and enantioselectivity. Such units, assembled together by Coulombic and/or hydrophobic forces, should form an innovative catalyst conjugating activity with enantioselectivity; (2) to validate the MODUCAT ideas in model catalytic asymmetric processes carried out in aqueous media. While the few known examples of "modular catalysts" find application in non-polar media, we propose to use Ag/Au NPs functionalized with SAMs of optically active charged molecules to bring about the modular approach in polar solvents. While the Fellow's background in catalysis, organometallic/colloidal chemistry, particularly dealing with charged NPs, is a big asset that guarantees high chance to reach the goals of the project, his training in preparation of water soluble catalysts and their application to aqueous systems, where the Host has a recognized experience, is a fundamental prerequisite for the success of the project.'