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ADIPOA

ADIPOSE DERIVED STROMAL CELLS FOR OSTEOARTHRITIS

Coordinatore	CENTRE HOSPITALIER UNIVERSITAIRE DE MONTPELLIER Organization address address: Avenue du Doyen Gaston Giraud 191 city: MONTPELLIER postcode: 34295 contact info Titolo: Ms. Nome: Valérie Cognome: Handweiler Email: send email Telefono: +33 4 67 33 90 43 Fax: +33 4 67 33 08 24
Nazionalità Coordinatore	France [FR]
Totale costo	12˙083˙457 €
EC contributo	9˙224˙472 €
Programma	FP7-HEALTH Specific Programme "Cooperation": Health
Code Call	FP7-HEALTH-2009-single-stage
Funding Scheme	CP-IP
Anno di inizio	2010
Periodo (anno-mese-giorno)	2010-01-01 - 2014-06-30

Partecipanti

#	participant	country	role	EC contrib. [€]
1	CENTRE HOSPITALIER UNIVERSITAIRE DE MONTPELLIER Organization address address: Avenue du Doyen Gaston Giraud 191 city: MONTPELLIER postcode: 34295 contact info Titolo: Ms. Nome: Valérie Cognome: Handweiler Email: send email Telefono: +33 4 67 33 90 43 Fax: +33 4 67 33 08 24	FR (MONTPELLIER)	coordinator	2˙167˙455.00
2	UNIVERSITATSKLINIKUM ERLANGEN Organization address address: Maximiliansplatz 2 city: ERLANGEN postcode: 91054 contact info Titolo: Dr. Nome: Katrin Cognome: Faber Email: send email Telefono: +49 9131 85-35902 Fax: +49 9131 85-35903	DE (ERLANGEN)	participant	889˙944.00
3	JULIUS-MAXIMILIANS UNIVERSITAET WUERZBURG Organization address address: SANDERRING 2 city: WUERZBURG postcode: 97070 contact info Titolo: Mr. Nome: Christian Cognome: Gloggengiesser Email: send email Telefono: +49 931-3182294 Fax: +49 931-3187180	DE (WUERZBURG)	participant	848˙150.00
4	ISTITUTO ORTOPEDICO RIZZOLI Organization address address: VIA DI BARBIANO 1/10 city: BOLOGNA postcode: 40136 contact info Titolo: Dr. Nome: Andrea Cognome: Rizzi Email: send email Telefono: +39 051 6366923 Fax: +39 051 6366702-	IT (BOLOGNA)	participant	769˙750.00
5	MRB Forschungszentrum fur Magnet-Resonanz-Bayern e.V. Organization address address: Am Hubland city: Wuerzburg postcode: 97074 contact info Titolo: Dr. Nome: Karl-Heinz Cognome: Hiller Email: send email Telefono: +49 931 31 83060 Fax: +49 931 888 4680	DE (Wuerzburg)	participant	693˙440.00
6	STICHTING KATHOLIEKE UNIVERSITEIT Organization address address: GEERT GROOTEPLEIN NOORD 9 city: NIJMEGEN postcode: 6525 EZ contact info Titolo: Mr. Nome: Maarten Cognome: Van Langen Email: send email Telefono: +31 24 3610791 Fax: +31 24 354 0529	NL (NIJMEGEN)	participant	636˙320.00
7	ETABLISSEMENT FRANCAIS DU SANG Organization address address: AVENUE DU STADE DE FRANCE 20 city: LA PLAINE SAINT DENIS CEDEX postcode: 93218 contact info Titolo: Dr. Nome: François Cognome: Destruel Email: send email Telefono: +33 5 61 31 20 05 Fax: +33 5 61 31 20 25	FR (LA PLAINE SAINT DENIS CEDEX)	participant	634˙687.00
8	VALSTYBINIS MOKSLINIU TYRIMU INSTITUTAS INOVATYVIOS MEDICINOS CENTRAS Organization address address: ZYGIMANTU 9 city: VILNIUS postcode: 1102 contact info Titolo: Prof. Nome: Jolanta Cognome: Dadoniene Email: send email Telefono: +370 52629485 Fax: 37052123073	LT (VILNIUS)	participant	596˙712.00
9	PROCORE LTD Organization address address: GOLDA MEIR 7 WEIZMANN SCIENCE PARK 7 city: NES ZIONA postcode: 70400 contact info Titolo: Prof. Nome: Avner Cognome: Yayon Email: send email Telefono: +972 8 910 1011 Fax: +972 8 936 7544	IL (NES ZIONA)	participant	576˙600.00
10	CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE Organization address address: Rue Michel -Ange 3 city: PARIS postcode: 75794 contact info Titolo: Dr. Nome: Armelle Cognome: Barelli Email: send email Telefono: +33 5 61 33 60 80 Fax: +33 5 62 17 29 01	FR (PARIS)	participant	548˙098.00
11	NATIONAL UNIVERSITY OF IRELAND, GALWAY Organization address address: University Road - city: GALWAY contact info Titolo: Mr. Nome: Roger Cognome: Sweetman Email: send email Telefono: -492383 Fax: -495238	IE (GALWAY)	participant	477˙616.00
12	Laboratoires MABIO International Organization address address: du Pont Rompu 96 city: Tourcoing postcode: 59203 contact info Titolo: Mr. Nome: Dominique Cognome: Malard Email: send email Telefono: +33 3 20 23 41 96 Fax: +33 3 20 23 40 86	FR (Tourcoing)	participant	385˙700.00

Mappa

Word cloud

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sme medicine us stem cells regenerative osteoarthritis adipoa wp clinical optimisation adipose knee cell vivo procedure trial asc biology validation effect intraarticular cartilage stromal chondroprotective shown therapy regulatory oa endogenous middot

Obiettivo del progetto (Objective)

'Osteoarthritis (OA) is a degenerative joint disease for which no efficient therapy is available. The ADIPOA consortium has previously shown that intraarticular injections of stromal cells prevents OA in two different models, but the mechanisms of this chondroprotective effect remains unknown, and the activation of cartilage derived endogenous stem cells is suspected. The participants have experience on cell therapy, logistic and production facilities for adipose derived stromal cells (ASC) and clinical studies focusing on cartilage repair. They have shown that stromal cells have anti-inflammatory and antiapoptosis effets, prevent cells from senescence and protect endogenous cells from oxidative stress. ASC are well described, and the procedure to expand the ASC in GMP clinical grade by one of us has been approved by regulatory authorities. This has prompted us to propose an original and innovative regenerative medicine approach for OA in a four years programme organised around 6 workpackages : · WP 1 ASC biology, cell processing & optimization for chondral protection · WP 2 In vivo validation of chondroprotective effect of ASC · WP 3 Safety, Security & regulatory issues · WP 4 Clinical trial endogenous ASC injected intraarticular in OA · WP 5 Management and Coordination · WP 6 Training and Education ADIPOA project will then lead to the optimisation and standardisation of production procedures. In vivo validation and optimisation shall lead to a phase 1 clinical trial and the design and initiation of a phase 2 controlled study in OA. The ADIPOA Consortium comprises 10 academic and 2 sme participants and gathers researchers and clinicians with expertise in clinical research, chondrocytes and adipose stem cell biology and regenerative medicine. The Sme participation will ensure the dissemination of the project results. The critical mass achieved by the ADIPOA Consortium should enable clinical applications in OA.'

Introduzione (Teaser)

Knee osteoarthritis (OA) affects millions of people in Europe with improved mobility possible only through knee arthroplasty, a surgical procedure. Fat-derived stem cells could prove to be a better solution.