5HT-OPTOGENETICS

Optogenetic Analysis of Serotonin Function in the Mammalian Brain

Coordinatore	FUNDACAO D. ANNA SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD    more Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.
Nazionalità Coordinatore	Portugal [PT]
Totale costo	2˙318˙636 €
EC contributo	2˙318˙636 €
Programma	FP7-IDEAS-ERC Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	ERC-2009-AdG
Funding Scheme	ERC-AG
Anno di inizio	2010
Periodo (anno-mese-giorno)	2010-07-01   -   2015-12-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	FUNDACAO CALOUSTE GULBENKIAN  Organization address address: AVENIDA DE BERNA 45A city: LISBOA postcode: 1000 contact info Titolo: Mr. Nome: José Mario Cognome: Leite Email: send email Telefono: +351 214407937 Fax: +351 214407970	PT (LISBOA)	beneficiary	917˙122.41
2	FUNDACAO D. ANNA SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD  Organization address address: AVENIDA BRASILIA city: LISBOA postcode: 1400 038 contact info Titolo: Dr. Nome: Tania Cognome: Vinagre Email: send email Telefono: 351210000000 Fax: 351210000000	PT (LISBOA)	hostInstitution	1˙401˙513.99
3	FUNDACAO D. ANNA SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD  Organization address address: AVENIDA BRASILIA city: LISBOA postcode: 1400 038 contact info Titolo: Dr. Nome: Zachary Cognome: Mainen Email: send email Telefono: +351 210480200 Fax: +351 210480299	PT (LISBOA)	hostInstitution	1˙401˙513.99

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 Obiettivo del progetto (Objective)

'Serotonin (5-HT) is implicated in a wide spectrum of brain functions and disorders. However, its functions remain controversial and enigmatic. We suggest that past work on the 5-HT system have been significantly hampered by technical limitations in the selectivity and temporal resolution of the conventional pharmacological and electrophysiological methods that have been applied. We therefore propose to apply novel optogenetic methods that will allow us to overcome these limitations and thereby gain new insight into the biological functions of this important molecule. In preliminary studies, we have demonstrated that we can deliver exogenous proteins specifically to 5-HT neurons using viral vectors. Our objectives are to (1) record, (2) stimulate and (3) silence the activity of 5-HT neurons with high molecular selectivity and temporal precision by using genetically-encoded sensors, activators and inhibitors of neural function. These tools will allow us to monitor and control the 5-HT system in real-time in freely-behaving animals and thereby to establish causal links between information processing in 5-HT neurons and specific behaviors. In combination with quantitative behavioral assays, we will use this approach to define the role of 5-HT in sensory, motor and cognitive functions. The significance of the work is three-fold. First, we will establish a new arsenal of tools for probing the physiological and behavioral functions of 5-HT neurons. Second, we will make definitive tests of major hypotheses of 5-HT function. Third, we will have possible therapeutic applications. In this way, the proposed work has the potential for a major impact in research on the role of 5-HT in brain function and dysfunction.'