MEMO-B
The B cell memory program: cell fate determinants and functional diversity of B cell subsets
| Coordinatore | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie. |
| Nazionalità Coordinatore | France [FR] |
| Totale costo | 1˙695˙980 € |
| EC contributo | 1˙695˙980 € |
| Programma | FP7-IDEAS-ERC
Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) |
| Code Call | ERC-2009-AdG |
| Funding Scheme | ERC-AG |
| Anno di inizio | 2010 |
| Periodo (anno-mese-giorno) | 2010-07-01 - 2015-06-30 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
Organization address
address: 101 Rue de Tolbiac contact info |
FR (PARIS) | hostInstitution | 1˙695˙980.00 |
| 2 |
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
Organization address
address: 101 Rue de Tolbiac contact info |
FR (PARIS) | hostInstitution | 1˙695˙980.00 |
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Obiettivo del progetto (Objective)
'B cells are responsible for the humoral arm of the immune response and most successful vaccines in humans are antibody-based. Depending on the pathogen, specific B cell subsets are mobilized and a variety of innate, intermediate or adaptive responses are produced. In some cases these responses generate memory in anticipation of a re-encounter with the same pathogen. B cells can also present antigens to T cells, and enhance or suppress immune responses, depending in which T cell context they are primed. The present project aims to describe new innate-like and memory B cell subsets and to unravel the molecular switch allowing the differentiation and the long-term maintenance into the memory program. This will be done by combining approaches in both humans and mice, in order to reveal the analogies and the differences between these two immune systems. Our main specific aims are 1) to establish a reporter cell line that, by complementation with a cDNA library from human centrocytes and memory B cells, should allow the identification of a master gene able to trigger the memory program 2) to compare various antigenic and endogenous stimuli in terms of formation of various innate-like and memory subsets, using a mouse model that, by marking irreversibly B cells during an immune response, has allowed us to reveal new layers of B-cell memory 3) to study the endogenous and exogenous signals that support the development of marginal zone B cells in humans 4) to unravel the genes that govern long-term B cell memory, by isolating anti-vaccinia virus long-lived human memory B cells. The general ambition is to provide new insights into the complexity of the B cell compartment that should allow the improvement of B-cell targeted vaccination strategies.'