HYGIENE
THE HYGIENE HYPOTHESIS : REVISITING THE CONCEPT BY INTEGRATING EPIDEMIOLOGY AND MECHANISTIC STUDIES
| Coordinatore | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie. |
| Nazionalità Coordinatore | France [FR] |
| Totale costo | 2˙099˙999 € |
| EC contributo | 2˙099˙999 € |
| Programma | FP7-IDEAS-ERC
Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) |
| Code Call | ERC-2009-AdG |
| Funding Scheme | ERC-AG |
| Anno di inizio | 2010 |
| Periodo (anno-mese-giorno) | 2010-08-01 - 2015-07-31 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI
Organization address
address: Via Giuseppe La Masa 19 contact info |
IT (MILANO) | beneficiary | 1˙001˙679.00 |
| 2 |
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
Organization address
address: 101 Rue de Tolbiac contact info |
FR (PARIS) | hostInstitution | 1˙098˙320.00 |
| 3 |
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
Organization address
address: 101 Rue de Tolbiac contact info |
FR (PARIS) | hostInstitution | 1˙098˙320.00 |
Mappa
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Obiettivo del progetto (Objective)
'The hygiene hypothesis postulating the paradoxical protective role of infections on immune-mediated diseases including atopy (i.e. atopic dermatitis, rhinitis, asthma) and more recently autoimmune diseases has been the matter of extensive investigation. The aim of the present project is to validate this hypothesis integrating epidemiological and experimental studies. We will review in a meta-analysis published studies of direct and indirect markers of infections and atopic diseases, and conduct a case-control study to analyse the association between infections and atopy using atopic dermatitis as a prototypic model. This epidemiological study will assess the occurrence of different infections and other risk factors related to the incidence of atopic dermatitis in children under age five in Italy (300 cases and 600 controls). This epidemiological study will be supported by experimental approaches addressing mechanistic questions raised by the hygiene hypothesis. Experimental models will include induction of acute and chronic bronchoconstriction/asthma, atopic dermatitis. In addition the project will aim at devising new mouse models of atopy. The nature of infections providing protection against allergic diseases will be investigated to characterise the difference at the molecular level between protective and non protective pathogens or their derivatives. The underlying immune mechanisms notably homeostasis imbalance, antigenic competition, stimulation of regulatory immune cells and Toll-like receptor involvement will be analysed. In addition to developing integrated in vivo models, including the use of transgenic animals, efforts will be focussed on the study of available synthetic pathogen-derived compounds showing a protective activity to better approach their cellular and molecular mode of action. These studies may pave the way to novel and safe therapies that could advantageously substitute for the “protective” immune stimulation induced by major infections.'