MEIOTIC CENTROMERES

Function of centromeres during meiotic bouquet stage and protein composition of telomeres

Coordinatore	CANCER RESEARCH UK    more  Organization address address: ST JOHN STREET 407 ANGEL BUILDING city: LONDON postcode: EC1V 4AD contact info Titolo: Ms. Nome: Holly Cognome: Elphinstone Email: send email Telefono: +44 20 7269 3524 Fax: +44 20 7269 3585
Nazionalità Coordinatore	United Kingdom [UK]
Totale costo	182˙103 €
EC contributo	182˙103 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2009-IEF
Funding Scheme	MC-IEF
Anno di inizio	2012
Periodo (anno-mese-giorno)	2012-07-31   -   2014-07-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	CANCER RESEARCH UK  Organization address address: ST JOHN STREET 407 ANGEL BUILDING city: LONDON postcode: EC1V 4AD contact info Titolo: Ms. Nome: Holly Cognome: Elphinstone Email: send email Telefono: +44 20 7269 3524 Fax: +44 20 7269 3585	UK (LONDON)	coordinator	182˙103.20

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 Obiettivo del progetto (Objective)

'Meiosis is a fundamental process in cell biology. During meiosis several unique features events occur such as segregation of homologs rather than sister chromatids and repair of double strand breaks by recombination of the homologs happen. During the first reductional meiotic division, the telomeres cluster in a formation called "bouquet". The bouquet is important for the establishment and maturation of the spindle during meiosis, and is conserved in evolution. Initial results lead us to suspect that the bouquet might affect chromosome segregation through effect on meiotic centromeres. In my this project I intend to study the effect of bouquet disruption on the protein composition and microtubules attachment of centromeres during S. pombe meiosis. I plan to investigate the possibility that a cis effect is mediated between the telomeres and the centromere of the same chromosome. This study will be conductedwill be accomplished by live cell imaging using fluorescent microscopy, together with advanced genetic techniques available in fission yeast. In addition, I intend to isolate all the proteins associated with a pombe telomere. This will be accomplished by using the newly developed PICh technique, and by careful quantification of the yield and use of a unique control without telomeres available only in fission yeast.'