CPAF

Calcium Propagation in Atrial Fibrillation

Coordinatore	KATHOLIEKE UNIVERSITEIT LEUVEN    more  Organization address address: Oude Markt 13 city: LEUVEN postcode: 3000 contact info Titolo: Dr. Nome: Delauré Cognome: Stijn Email: send email Telefono: -1248 Fax: -506
Nazionalità Coordinatore	Belgium [BE]
Totale costo	166˙800 €
EC contributo	166˙800 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2009-IEF
Funding Scheme	MC-IEF
Anno di inizio	2010
Periodo (anno-mese-giorno)	2010-03-01   -   2012-02-29

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	KATHOLIEKE UNIVERSITEIT LEUVEN  Organization address address: Oude Markt 13 city: LEUVEN postcode: 3000 contact info Titolo: Dr. Nome: Delauré Cognome: Stijn Email: send email Telefono: -1248 Fax: -506	BE (LEUVEN)	coordinator	166˙800.00

Mappa

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 Obiettivo del progetto (Objective)

'Synchronized release of Ca2 from the internal Ca2 store of cardiac myocytes, the sarcoplasmic reticulum, is essential for a normal heart beat. This is obtained through a sophisticated subcellular organization, the dyad. In dyads, a cluster of release channels in the sarcoplasmic reticulum, ryanodine receptors or RyRs, face Ca2 channels in the cell membrane, the dihydropyrydine receptors or DHPRs. DHPRs provide the Ca2 influx that triggers opening of RyR. Ca2 release can also propagate between RyR, leading to Ca2 waves that can initiate arrhythmias. We hypothesize that RyR that are not within dyads have different properties that may facilitate wave-like propagation and arrhythmias. The objectives are (1) to identify and characterize RyR located between dyads in the sarcomeric space in healthy myocytes (2) to establish whether altered organization and properties of RyRs in chronic atrial fibrillation (AF) contribute to the contractile dysfunction and arrhythmia in AF. My stay in the host lab will provide a clinical and translational perspective to my current knowledge enhancing the potential impact of my research. An interdisciplinary approach for imaging of RyR with access to novel microscopic techniques in the Molecular engineering department and tools for image analysis with the Medical Imaging Center and ESAT will enhance my technological expertise.'