MITOSYS
Systems Biology of Mitosis
| Coordinatore | FORSCHUNGSINSTITUT FUER MOLEKULARE PATHOLOGIE Ges.m.b.H
Organization address
address: Dr. Bohr-Gasse 7 contact info |
| Nazionalità Coordinatore | Austria [AT] |
| Totale costo | 15˙075˙776 € |
| EC contributo | 10˙198˙241 € |
| Programma | FP7-HEALTH
Specific Programme "Cooperation": Health |
| Code Call | FP7-HEALTH-2009-two-stage |
| Funding Scheme | CP-IP |
| Anno di inizio | 2010 |
| Periodo (anno-mese-giorno) | 2010-06-01 - 2015-05-31 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
FORSCHUNGSINSTITUT FUER MOLEKULARE PATHOLOGIE Ges.m.b.H
Organization address
address: Dr. Bohr-Gasse 7 contact info |
AT (VIENNA) | coordinator | 1˙563˙265.80 |
| 2 |
MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.
Organization address
address: Hofgartenstrasse 8 contact info |
DE (MUENCHEN) | participant | 2˙377˙523.00 |
| 3 |
EUROPEAN MOLECULAR BIOLOGY LABORATORY
Organization address
address: Meyerhofstrasse 1 contact info |
DE (HEIDELBERG) | participant | 1˙375˙434.00 |
| 4 |
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Organization address
address: University Offices, Wellington Square contact info |
UK (OXFORD) | participant | 979˙245.00 |
| 5 |
TECHNISCHE UNIVERSITEIT DELFT
Organization address
address: Stevinweg 1 contact info |
NL (DELFT) | participant | 555˙581.00 |
| 6 |
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Organization address
address: Rue Michel -Ange 3 contact info |
FR (PARIS) | participant | 554˙273.00 |
| 7 |
FUNDACION CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III
Organization address
address: CALLE MELCHOR FERNANDEZ ALMAGRO 3 contact info |
ES (MADRID) | participant | 525˙605.00 |
| 8 |
INSTITUT CURIE
Organization address
address: 26, rue d'Ulm contact info |
FR (PARIS) | participant | 500˙800.00 |
| 9 |
INSTITUT FUER MOLEKULARE BIOTECHNOLOGIE GMBH
Organization address
address: Dr Bohrgasse 3 contact info |
AT (VIENNA) | participant | 462˙688.06 |
| 10 |
CARL ZEISS MICROSCOPY GMBH
Organization address
address: Carl Zeiss Promenade 10 contact info |
DE (Jena) | participant | 452˙491.00 |
| 11 |
THE UNIVERSITY OF THE ARTS LONDON
Organization address
address: 272 HIGH HOLBURN contact info |
UK (LONDON) | participant | 320˙826.20 |
| 12 |
MEDICAL RESEARCH COUNCIL
Organization address
address: NORTH STAR AVENUE POLARIS HOUSE contact info |
UK (SWINDON) | participant | 275˙900.00 |
| 13 |
ISTITUTO EUROPEO DI ONCOLOGIA SRL
Organization address
address: Via Filodrammatici 10 contact info |
IT (MILANO) | participant | 164˙297.00 |
| 14 |
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZURICH
Organization address
address: Raemistrasse 101 contact info |
CH (ZUERICH) | participant | 90˙311.93 |
Mappa
Word cloud
Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.
Obiettivo del progetto (Objective)
'MitoSys will generate a comprehensive mathematical understanding of mitotic division in human cells, a process of fundamental importance for human health. To create the critical mass and multidisciplinarity that is needed to achieve this ambitious goal, internationally leading mathematicians, biochemists/biophysicists and biologists working at twelve universities, research institutes, international organizations and companies in eight different European countries will collaborate. Mathematicians will focus on four biological modules that represent the most important aspects of the mitotic cell division process; (i) spindle assembly, (ii) the spindle assembly checkpoint and kinetochores, (iii) segregation of mitotic chromosomes and (iv) mitotic exit. Computational models of these separate modules will be integrated into a comprehensive model of mitosis that combines these steps of mitosis with regulation by protein kinases and ubiquitin ligases. To be able to achieve these tasks, the modellers will be supported by biologists and physicists who will use microscopic imaging, biochemistry, biophysics, single-molecule techniques and proteomics to generate kinetic and other quantitative data suitable for model building. To evaluate the relevance of the mathematical models for human health and disease, other biologists will subject selected key predictions from these models to rigorous in-vivo tests by using conditional 'knock-out' mice. MitoSys will compile and disseminate its own data and models, but also datasets from public sources, in a web-database, which will serve as a systems biology resource for the scientific community. To train other scientists in systems biology, MitoSys will organize a practical workshop on mathematical modelling. Finally, MitoSys will inform the general public about systems biology of mitosis and its relevance to health and disease by organizing an exhibition, which will be displayed in several European cities.'
Introduzione (Teaser)
A cell's nucleus divides after replication of its nuclear components during mitosis. This process is fundamental to sustaining life and elucidating underlying mechanisms could be the key to the understanding of various diseases and innovative therapies.
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