MARK-AGE
European Study to Establish Biomarkers of Human Ageing
| Coordinatore | UNIVERSITAT KONSTANZ
Organization address
address: UNIVERSITATSSTRASSE 10 contact info |
| Nazionalità Coordinatore | Germany [DE] |
| Sito del progetto | http://www.mark-age.eu/ |
| Totale costo | 15˙907˙409 € |
| EC contributo | 11˙989˙327 € |
| Programma | FP7-HEALTH
Specific Programme "Cooperation": Health |
| Code Call | FP7-HEALTH-2007-A |
| Funding Scheme | CP-IP |
| Anno di inizio | 2008 |
| Periodo (anno-mese-giorno) | 2008-04-01 - 2013-09-30 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
UNIVERSITAT KONSTANZ
Organization address
address: UNIVERSITATSSTRASSE 10 contact info |
DE (KONSTANZ) | coordinator | 0.00 |
| 2 |
AARHUS UNIVERSITET
Organization address
address: Nordre Ringgade 1 contact info |
DK (AARHUS C) | participant | 0.00 |
| 3 |
ACADEMISCH ZIEKENHUIS LEIDEN
Organization address
address: Albinusdreef 2 contact info |
NL (LEIDEN) | participant | 0.00 |
| 4 |
ALMA MATER STUDIORUM-UNIVERSITA DI BOLOGNA
Organization address
address: Via Zamboni 33 contact info |
IT (BOLOGNA) | participant | 0.00 |
| 5 |
ANA ASLAN INSTITUTE OF GERONTOLOGY AND GERIATRICS
Organization address
address: STRADA MANASTIREA CALDARUSANI 9 contact info |
RO (BUCHAREST) | participant | 0.00 |
| 6 |
ASTON UNIVERSITY
Organization address
address: ASTON TRIANGLE contact info |
UK (BIRMINGHAM) | participant | 0.00 |
| 7 |
BIOTESYS GMBH
Organization address
address: SCHELZTORSTRASSE 54-56 contact info |
DE (ESSLINGEN) | participant | 0.00 |
| 8 |
CRANFIELD UNIVERSITY
Organization address
address: College Road contact info |
UK (CRANFIELD - BEDFORDSHIRE) | participant | 0.00 |
| 9 |
DNAGE BV
Organization address
address: Darwinweg 24 contact info |
NL (LEIDEN) | participant | 0.00 |
| 10 |
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Organization address
address: 's Gravendijkwal 230 contact info |
NL (ROTTERDAM) | participant | 0.00 |
| 11 |
ETHNIKO IDRYMA EREVNON
Organization address
address: Vassileos Constantinou Avenue 48 contact info |
EL (ATHENS) | participant | 0.00 |
| 12 |
FUNDACION CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III
Organization address
address: CALLE MELCHOR FERNANDEZ ALMAGRO 3 contact info |
ES (MADRID) | participant | 0.00 |
| 13 |
IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE
Organization address
address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD contact info |
UK (LONDON) | participant | 0.00 |
| 14 |
INSTYTUT BIOLOGII DOSWIADCZALNEJ IM. M. NENCKIEGO POLSKIEJ AKADEMII NAUK
Organization address
address: UL. LUDWIKA PASTEURA 3 contact info |
PL (WARSZAWA) | participant | 0.00 |
| 15 |
ISTITUTO NAZIONALE DI RIPOSO E CURA PER ANZIANI INRCA
Organization address
address: Via Santa Margherita 5 contact info |
IT (ANCONA) | participant | 0.00 |
| 16 |
MARTIN-LUTHER-UNIVERSITAET HALLE-WITTENBERG
Organization address
address: UNIVERSITAETSPLATZ 10 contact info |
DE (HALLE (Saale)) | participant | 0.00 |
| 17 |
NESTEC S.A
Organization address
address: Avenue Nestle 55 contact info |
CH (VEVEY) | participant | 0.00 |
| 18 |
OESTERREICHISCHE AKADEMIE DER WISSENSCHAFTEN
Organization address
address: DR. IGNAZ SEIPEL-PLATZ 2 contact info |
AT (WIEN) | participant | 0.00 |
| 19 |
RIJKSINSTITUUT VOOR VOLKSGEZONDHEIDEN MILIEU*NATIONAL INSTITUTEFOR PUBLIC HEALTH AND THE ENVIRONMENTEN
Organization address
address: Antonie Van Leeuwenhoeklaan 9 contact info |
NL (BILTHOVEN) | participant | 0.00 |
| 20 |
STRATICELL SCREENING TECHNOLOGIES
Organization address
address: RUE JEAN SONET 10 PARC SCIENTIFIQUE CREALYS CRI ANDROMEDE contact info |
BE (GEMBLOUX LES ISNES) | participant | 0.00 |
| 21 |
TAMPEREEN YLIOPISTO
Organization address
address: Kalevantie 4 contact info |
FI (TAMPERE) | participant | 0.00 |
| 22 |
UNILEVER U.K. CENTRAL RESOURCES LIMITED
Organization address
address: "UNILEVER HOUSE, VICTORIA EMBANKMENT 100" contact info |
UK (LONDON) | participant | 0.00 |
| 23 |
UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA
Organization address
address: Piazzale Aldo Moro 5 contact info |
IT (ROMA) | participant | 0.00 |
| 24 |
UNIVERSITAET HOHENHEIM
Organization address
address: Schloss Hohenheim 1 contact info |
DE (STUTTGART) | participant | 0.00 |
| 25 |
UNIVERSITAET INNSBRUCK
Organization address
address: INNRAIN 52 contact info |
AT (INNSBRUCK) | participant | 0.00 |
| 26 |
UNIVERSITE DE NAMUR ASBL
Organization address
address: Rue de Bruxelles 61 contact info |
BE (NAMUR) | participant | 0.00 |
| 27 |
UNIVERSITE PIERRE ET MARIE CURIE - PARIS 6
Organization address
address: Place Jussieu 4 contact info |
FR (PARIS) | participant | 0.00 |
| 28 |
VIB
Organization address
address: Rijvisschestraat 120 contact info |
BE (ZWIJNAARDE - GENT) | participant | 0.00 |
Mappa
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Obiettivo del progetto (Objective)
'The rate of ageing in humans is not uniform, due to genetic heterogeneity and the influence of environmental factors. Age-related changes in body function or composition that could serve as a measure of “biological” age and predict the onset of age-related diseases and/or residual lifetime are termed “biomarkers of ageing”. Many candidate biomarkers have been proposed but in all cases their variability in cross-sectional studies is considerable, and therefore no single measurement has so far proven to yield a useful biomarker of ageing on its own, probably due to the multi-causal and multi-system nature of ageing. We propose to conduct a population study (3,300 probands) to identify a set biomarkers of ageing which, as a combination of parameters with appropriate weighting, would measure biological age better than any marker in isolation. Two large groups of subjects will be recruited, i.e. (1) randomly recruited age-stratified individuals from the general population covering the age range 35-74 years and (2) subjects born from a long-living parent belonging to a family with long living sibling(s) already recruited in the framework of the GEHA project. For genetic reasons such individuals (“GEHA offspring”) are expected to age at a slower rate. They will be recruited together with their spouses as controls, thus allowing initial validation of the biomarkers identified. (3) A small number of patients with progeroid syndromes will also be included in the study. A wide range of candidate biomarkers will be tested, including (a) “classical” ones for which data from several smaller studies have been published; (b) “new” ones, based on recent preliminary data, as well as (c) “novel” ones, based on recent research on mechanistic aspects of ageing, conducted by project participants. Bioinformatics will be used in order to extract a robust set of biomarkers of human ageing from the large amounts of data to be generated and to derive a model for healthy ageing.'
Introduzione (Teaser)
Ageing is an unavoidable process which brings along physical deterioration as well as age-related diseases. European researchers aimed to develop a mathematical model that could compute one's biological age based on a set of biomarkers.
Descrizione progetto (Article)
Genetic heterogeneity as well as environmental factors influence the rate of human ageing. To measure the true biological age of an individual and predict the onset of diseases, identifying age-related changes that serve as biomarkers is necessary.
Although many candidate biomarkers have been proposed, no single measurement has proven useful. This could be due to the multi-system nature of ageing which requires multiple parameters to be analysed at once. In this context, the EU-funded 'European study to establish biomarkers of human ageing' (http://www.mark-age.eu (MARK-AGE)) study proposed to identify a set of biomarkers of ageing to measure biological age accurately.
To achieve this, MARK-AGE partners performed a large study of over 2 300 individuals of different ages from seven locations across Europe. Another study group contained subjects born from a long-living parent belonging to a family with long-living siblings.
All enrolled subjects provided anthropometric, clinical and social information. Physical examination included measurements such as body mass index, waist and hip circumference as well as blood pressure and heart rate. In addition, subjects donated peripheral blood for further genetic and immunophenytoping analysis.
A series of putative DNA-based markers were examined such as DNA methylation, DNA repair and chromosome length. At the protein level, researchers looked at certain protein modifications and signs of protein damage. Since immune responses diminish with ageing, a number of immunological parameters were also evaluated such as antibody and cytokine levels. The study additionally included assays for measuring markers of metabolism and oxidative stress.
Out of these biomarkers, ten were selected based on their ability to better correlate the biological with the chronological age in the population. The results of assaying for these biomarkers were subsequently used to calculate a score that served as a prediction of an individual's biological age.
The long-term goal of the MARK-AGE study was to develop a mathematical model that could calculate one's biological age utilising these 10 biomarkers. This could help develop novel strategies for preventing accelerated ageing for a healthier lifestyle.
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