MOBA-CS

The molecular basis of Cockayne Syndrome

 Coordinatore FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH 

Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.

 Nazionalità Coordinatore Switzerland [CH]
 Totale costo 1˙499˙235 €
 EC contributo 1˙499˙235 €
 Programma FP7-IDEAS-ERC
Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call ERC-2010-StG_20091118
 Funding Scheme ERC-SG
 Anno di inizio 2011
 Periodo (anno-mese-giorno) 2011-01-01   -   2015-12-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    Novartis Forschungsstiftung

 Organization address address: Maulbeerstrasse 66
city: BASEL
postcode: 4058

contact info
Titolo: Ms.
Nome: Dorothy
Cognome: Searles
Email: send email
Telefono: +41 61 6972982
Fax: +41 61 6973976

CH (BASEL) beneficiary 0.00
2    FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH

 Organization address address: MAULBEERSTRASSE 66
city: BASEL
postcode: 4058

contact info
Titolo: Dr.
Nome: Nicolas
Cognome: Thomä
Email: send email
Telefono: +41 61 697 86 30
Fax: +41 61 69739 76

CH (BASEL) hostInstitution 1˙499˙235.00
3    FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH

 Organization address address: MAULBEERSTRASSE 66
city: BASEL
postcode: 4058

contact info
Titolo: Mrs.
Nome: Searles
Cognome: Dorothy
Email: send email
Telefono: +41 61 6972982
Fax: +41 61 6973976

CH (BASEL) hostInstitution 1˙499˙235.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

repair    rna    damage    ubiquitin    ddb    ligase    stalled    cockayne    csa    rbx    syndrome    pathway    coupled    recruitment    pursue    function    transcription    sites    dna    cul    proteomic    csb    structure    substrate    genes   

 Obiettivo del progetto (Objective)

'Cockayne syndrome is a congenital disease with impaired DNA repair in actively transcribed genes. Affected children show developmental abnormalities and signs of premature aging. Cockayne syndrome is caused by mutations in the Cockayne syndrome complementation group A (CSA) and B (CSB) genes. While CSB encodes a SWI/SNF ATPase that likely assists the stalled RNA polymerase in overcoming lesions, CSA’s detailed role in repair has so far remained elusive. CSA is part of the DDB1-CSA-Cul4-Rbx1 E3 ubiquitin ligase complex. The available data suggest that CSA may function as a substrate adaptor for ubiquitination by the DDB1-Cul4-Rbx1 ligase. I will pursue a novel structure-driven proteomic approach to identify the substrate epitope recognized by the DDB1-CSA-Cul4-Rbx1 E3 ubiquitin ligase. These experiments aim to provide the important missing signal required for recruitment of the ligase complex to sites of stalled RNA polII complexes. Importantly, the CSA ligase, as it arrives at sites of DNA damage, is inactive. Our comprehensive structural and biochemical efforts will thus include the mechanisms of regulation of the CSA ubiquitin ligase activity by activators and inhibitors following recruitment to the repair site. MoBa-CS will not only improve our understanding of CSA’s molecular role in Cockayne syndrome, but also reveal CSA’s mode of action within the essential transcription coupled repair pathway. Understanding the cellular signals overseeing transcription coupled repair will provide important insights into how the pathway is integrated within the overall DNA damage response circuitry of the cell. ERC funding would enable us to pursue an interdisciplinary proteomic and structure based approach in examining DDB1-CSA function.'

Altri progetti dello stesso programma (FP7-IDEAS-ERC)

AFRIVAL (2009)

African river basins: catchment-scale carbon fluxes and transformations

Read More  

CAUSALPATH (2015)

Next Generation Causal Analysis: Inspired by the Induction of Biological Pathways from Cytometry Data

Read More  

GEPIDIAB (2012)

Genetics and epigenetics of Type 2 Diabetes physiology

Read More