VIRALPHYLOGEOGRAPHY

Evolutionary reconstruction of viral spread in time and space

Coordinatore	KATHOLIEKE UNIVERSITEIT LEUVEN    more Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.
Nazionalità Coordinatore	Belgium [BE]
Totale costo	1˙498˙915 €
EC contributo	1˙498˙915 €
Programma	FP7-IDEAS-ERC Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	ERC-2010-StG_20091118
Funding Scheme	ERC-SG
Anno di inizio	2010
Periodo (anno-mese-giorno)	2010-10-01   -   2015-09-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA  Organization address address: "FRANKLIN STREET 1111, 12 FLOOR" city: OAKLAND CA postcode: 94607 contact info Titolo: Ms. Nome: Martha Cognome: Hansen Email: send email Telefono: +1 310 794 0236 Fax: +1 310 794 0631	US (OAKLAND CA)	beneficiary	182˙614.95
2	THE UNIVERSITY OF EDINBURGH  Organization address address: OLD COLLEGE, SOUTH BRIDGE city: EDINBURGH postcode: EH8 9YL contact info Titolo: Ms. Nome: Angela Cognome: Noble Email: send email Telefono: +44 131 650 9024 Fax: +44 131 651 4028	UK (EDINBURGH)	beneficiary	134˙671.20
3	KATHOLIEKE UNIVERSITEIT LEUVEN  Organization address address: Oude Markt 13 city: LEUVEN postcode: 3000 contact info Titolo: Dr. Nome: Philippe Cognome: Lemey Email: send email Telefono: -332144 Fax: -332115	BE (LEUVEN)	hostInstitution	1˙181˙629.00
4	KATHOLIEKE UNIVERSITEIT LEUVEN  Organization address address: Oude Markt 13 city: LEUVEN postcode: 3000 contact info Titolo: Dr. Nome: Stijn Cognome: Delauré Email: send email Telefono: +32 16 320 944 Fax: +32 16 324 198	BE (LEUVEN)	hostInstitution	1˙181˙629.00

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 Obiettivo del progetto (Objective)

'To identify the causal mechanisms leading to disease emergence, endemic maintenance and epidemic expansion, epidemiologists would benefit tremendously from a full characterization of pathogen spread in space and time. The extensive sequencing efforts for the ongoing swine-origin H1N1 influenza A epidemic testify that analyses of pathogen genetic data are becoming increasingly important source of information in epidemiology. The new era of metagenomics promises to harvest such data in unprecedented quantities with remarkable rapidity. With the objective to assist in designing effective intervention and prevention strategies, we propose to develop a comprehensive statistical framework for uncovering the spatial and temporal dynamics of pathogen genomes. To this aim, we will design and extend a series of computationally tractable models that use the rapidly proliferating viral genome data to their full potential, connect molecular evolution to underlying spatial processes, and pave the path to rigorous and powerful phylogeographic hypothesis testing approaches. Armed with these tools, we will investigate how genetic variation within important viral pathogens, such as influenza, rabies and HIV, arises and persists across a diverse range of hosts and environments.'