SILENCING HORMONES

THE ROLE OF RNA SILENCING IN REGULATION OF JASMONATE HORMONE SIGNALLING

Coordinatore	AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS    more  Organization address address: CALLE SERRANO 117 city: MADRID postcode: 28006 contact info Titolo: Ms. Nome: María Angeles Cognome: López Vázquez Email: send email Telefono: +34 91 5681462 Fax: +34 91 5681573
Nazionalità Coordinatore	Spain [ES]
Totale costo	251˙679 €
EC contributo	251˙679 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2009-IOF
Funding Scheme	MC-IOF
Anno di inizio	2010
Periodo (anno-mese-giorno)	2010-06-01   -   2014-11-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS  Organization address address: CALLE SERRANO 117 city: MADRID postcode: 28006 contact info Titolo: Ms. Nome: María Angeles Cognome: López Vázquez Email: send email Telefono: +34 91 5681462 Fax: +34 91 5681573	ES (MADRID)	coordinator	251˙679.10

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 Obiettivo del progetto (Objective)

RNA silencing and jasmonate (JA) signalling are key pathways that regulate plant development and defence against pests and disease. Evidence indicates that these pathways interact, but the full extent and nature of the interactions are unknown. An accurate understanding of these interactions is crucial to inform crop modification strategies that improve plant defence and growth. RNA silencing targets specific genes using small (s)RNAs. It controls gene expression through processes such as DNA methylation, which affects binding of transcription factors (TFs) to promoters, and mRNA degradation. JA signalling may influence DNA methylation via RNA silencing, and expression of hundreds of genes changes during JA responses. Also, JA signalling is inhibited by disruption of RNA silencing. I propose to conduct a targeted dissection of JA signalling/RNA silencing interactions. I will be hosted first by Prof. Ecker (Salk Institute, US), who is a world leader in DNA methylation research. There, I will investigate JA-responsive changes in DNA methylation at a genome-wide scale. I will also study a group of TFs that regulate both RNA silencing and JA signalling, and investigate the roles of known RNA silencing components in JA responses. In the return phase, I will be hosted by Prof. Solano (Centro Nacional de Biotecnología, Spain) who is an expert in JA biology. Whilst in his group I will characterize novel JA-responsive sRNAs and investigate the effects of JA-responsive DNA-methylation on known JA-signalling TFs. These objectives will reveal new insights into two critical plant defence pathways, making an important contribution to the EU Knowledge Based Bio-Economy. Through significant international mobility, I will learn cutting-edge techniques, broaden my scientific knowledge, develop complementary skills such as lab management, and extend my professional network. These experiences will be crucial in attaining my goal of becoming a group leader.