GUMS AND JOINTS
Protein citrullination as a link between periodontal diseases and rheumatoid arthritis (RA) and target for development of novel drugs to treat RA
| Coordinatore | UNIVERSITETET I BERGEN
Organization address
address: Museplassen 1 contact info |
| Nazionalità Coordinatore | Norway [NO] |
| Sito del progetto | http://www.gumsandjoints.com |
| Totale costo | 7˙588˙334 € |
| EC contributo | 5˙851˙588 € |
| Programma | FP7-HEALTH
Specific Programme "Cooperation": Health |
| Code Call | FP7-HEALTH-2010-single-stage |
| Funding Scheme | CP-FP |
| Anno di inizio | 2010 |
| Periodo (anno-mese-giorno) | 2010-11-01 - 2014-10-31 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
UNIVERSITETET I BERGEN
Organization address
address: Museplassen 1 contact info |
NO (BERGEN) | coordinator | 705˙849.00 |
| 2 |
4 SC AG
Organization address
address: Am Klopferspitz 19 a contact info |
DE (Planegg-Martinsried) | participant | 703˙985.60 |
| 3 |
KAROLINSKA INSTITUTET
Organization address
address: Nobels Vag 5 contact info |
SE (STOCKHOLM) | participant | 545˙993.80 |
| 4 |
UNIVERSITY OF GLASGOW
Organization address
address: University Avenue contact info |
UK (GLASGOW) | participant | 542˙663.80 |
| 5 |
UNIWERSYTET JAGIELLONSKI
Organization address
address: Ul. Golebia 24 contact info |
PL (KRAKOW) | participant | 541˙741.50 |
| 6 |
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Organization address
address: University Offices, Wellington Square contact info |
UK (OXFORD) | participant | 514˙057.60 |
| 7 |
AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Organization address
address: CALLE SERRANO 117 contact info |
ES (MADRID) | participant | 503˙266.60 |
| 8 |
GOETEBORGS UNIVERSITET
Organization address
address: VASAPARKEN contact info |
SE (GOETEBORG) | participant | 498˙729.60 |
| 9 |
THE UNIVERSITY OF BIRMINGHAM
Organization address
address: Edgbaston contact info |
UK (BIRMINGHAM) | participant | 447˙759.80 |
| 10 |
UNIVERSITA DEGLI STUDI DI FIRENZE
Organization address
address: Piazza San Marco 4 contact info |
IT (Florence) | participant | 433˙146.70 |
| 11 |
AARHUS UNIVERSITET
Organization address
address: Nordre Ringgade 1 contact info |
DK (AARHUS C) | participant | 253˙504.80 |
| 12 |
ANAXOMICS BIOTECH, S.L.
Organization address
address: CALLE BALMES (PISO 4 - PTA 2A) 89 contact info |
ES (Barcelona) | participant | 160˙889.20 |
| 13 |
IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE
Organization address
address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD contact info |
UK (LONDON) | participant | 0.00 |
Mappa
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Obiettivo del progetto (Objective)
'Autoimmunity in rheumatoid arthritis (RA) is characterised by an antibody response to citrullinated proteins. Periodontitis (PD) is largely caused by infection, in which Porphyromonas gingivalis is a major pathogen. The two diseases combine specific HLA-DRB1alleles and smoking as risk factors, and have a similar pathophysiology characterised by destructive inflammation. A possible causative link between RA and PD is based on the ability of P. gingivalis to citrullinate proteins and thereby generate autoantigens that drive autoimmunity in RA. We hypothesise that anti-citrullinated protein antibodies can be generated, in genetically susceptible individuals, as a consequence of P. Gingivalis-induced citrullination in the gingiva. In the context of genetic risk factors, during chronic exposure to danger signals, such as bacterial lipopolysacharides and DNA, tolerance to citrullinated proteins may be broken, with production of a pathogenic antibody response, which at a later time point cross-reacts with joint proteins and causes chronic RA. We will use a multidisciplinary approach (genetics, epidemiology, molecular immunology and animal models) to study susceptibility factors and immune responses in RA and PD, with an aim to identify novel etiological and pathogenic pathways, forming the basis for new therapies.'
Introduzione (Teaser)
Identification of the epidemiological, genetic and environmental triggers of rheumatoid arthritis (RA) will aid the design of therapeutic interventions. In this context, European scientists discovered a link between RA and periodontitis (PD).