METAFLUX
Metabolic Flux Analysis and Cancer
| Coordinatore | THE UNIVERSITY OF BIRMINGHAM
Organization address
address: Edgbaston contact info |
| Nazionalità Coordinatore | United Kingdom [UK] |
| Totale costo | 4˙384˙122 € |
| EC contributo | 4˙384˙122 € |
| Programma | FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) |
| Code Call | FP7-PEOPLE-2010-ITN |
| Funding Scheme | MC-ITN |
| Anno di inizio | 2010 |
| Periodo (anno-mese-giorno) | 2010-11-01 - 2014-10-31 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
THE UNIVERSITY OF BIRMINGHAM
Organization address
address: Edgbaston contact info |
UK (BIRMINGHAM) | coordinator | 968˙978.92 |
| 2 |
UNIVERSITAT DE BARCELONA
Organization address
address: GRAN VIA DE LES CORTS CATALANES 585 contact info |
ES (BARCELONA) | participant | 719˙028.08 |
| 3 |
WEIZMANN INSTITUTE OF SCIENCE
Organization address
address: HERZL STREET 234 contact info |
IL (REHOVOT) | participant | 527˙681.26 |
| 4 |
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
Organization address
address: The Old Schools, Trinity Lane contact info |
UK (CAMBRIDGE) | participant | 522˙998.07 |
| 5 |
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Organization address
address: BATIMENT CE 3316 STATION 1 contact info |
CH (LAUSANNE) | participant | 501˙045.59 |
| 6 |
MAGYAR TUDOMANYOS AKADEMIA SZEGEDI BIOLOGIAI KOZPONTJA
Organization address
address: Temesvari krt. 62 contact info |
HU (SZEGED) | participant | 453˙424.51 |
| 7 |
BIOCRATES LIFE SCIENCES AG
Organization address
address: EDUARD BODEM GASSE 8 1 STOCK contact info |
AT (Innsbruck) | participant | 429˙294.34 |
| 8 |
OXFORD INSTRUMENTS MOLECULAR BIOTOOLS LIMITED
Organization address
address: Tubney Woods contact info |
UK (Abingdon) | participant | 261˙672.19 |
| 9 |
TEL AVIV UNIVERSITY
Organization address
address: RAMAT AVIV contact info |
IL (TEL AVIV) | participant | 0.00 |
Mappa
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Obiettivo del progetto (Objective)
'The post-genomic era has been driven by the development of technologies that allow the function of cells and whole organisms to be explored at a molecular level. Metabolomics is concerned with the measurement of global sets of low-molecular-weight metabolites, which represent important indicators of physiological or pathological states of organisms. Such profiles provide a more comprehensive view of cellular control mechanisms in man and animals, and raise the possibility of identifying surrogate markers of disease. Metabolomic approaches use analytical different techniques to measure populations of low-molecular-weight metabolites in biological samples. To decipher large metabolic data sets advanced statistical and bioinformatic tools are commonly employed. Although metabolomics has only recently emerged, dynamic profiles generated in Metabolic Flux Analysis (MFA) are becoming increasingly important to analyse biological networks in a quantitative manner and as part of systems biology approaches. MFA allows us to probe hypotheses by incorporating a priori biological knowledge to provide practical descriptions of observed cell behaviours, and to characterise the outcome of network perturbations. Flux analysis is of particular value for the diagnosis, differentiation and elucidation of mechanisms in cancer. This was recognised as early as 1924 by the Nobel Prize winner Otto Warburg who attributed cancer to a change in cellular energy production. This theme has experienced a revival in recent years through research, which has established mitochondrial dysfunction as a major mechanism in cancer. This proposal seeks funding for a truly interdisciplinary European consortium to train researchers to exploit the gains of new technologies provided by metabolic flux analysis in the context of cancer with a mixed focus on new developments and applied end-points.'
Introduzione (Teaser)
Metabolic flux is the movement of metabolites such as chemicals and molecules in cellular metabolic pathways. Cancer is believed to cause changes in metabolite regulation, the products of which could be used as markers in disease diagnosis.