PROBI

PRotein cOatings to prevent Bacterial Infections

Coordinatore	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD    more  Organization address address: University Offices, Wellington Square city: OXFORD postcode: OX1 2JD contact info Titolo: Ms. Nome: Linda Cognome: Pialek Email: send email Telefono: +44 1865 289800 Fax: +44 1865 289801
Nazionalità Coordinatore	United Kingdom [UK]
Totale costo	117˙213 €
EC contributo	117˙213 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2009-IEF
Funding Scheme	MC-IEF
Anno di inizio	2011
Periodo (anno-mese-giorno)	2011-09-12   -   2012-09-11

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD  Organization address address: University Offices, Wellington Square city: OXFORD postcode: OX1 2JD contact info Titolo: Ms. Nome: Linda Cognome: Pialek Email: send email Telefono: +44 1865 289800 Fax: +44 1865 289801	UK (OXFORD)	coordinator	117˙213.60

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 Obiettivo del progetto (Objective)

'Biomaterials are revolutionising many aspects of preventive and therapeutic healthcare. They are already playing an important role in the development of new medical devices, prostheses, tissue repair and replacement technologies. This proposal addresses two of the most critical issues in biomaterials research: lack of knowledge of the fundamentals processes underlying interfacial interactions and bacterial infection. We will focus our research on materials used for ophthalmological implants and in particular on the ones used in the manufacturing of intra-ocular lenses for cataract surgery. We will study the interaction of Staphilococcus epidermidis with biomaterial surfaces with nanoscience techniques. Staphilococcus epidermidis ranks first among the causative agents of nosocomial infections. In particular, S. epidermidis represents the most common source of infections on indwelling medical devices. Based on the knowledge accumulated in recent years about the characteristics that make a successful biocompatible interface we propose to research on the properties of amphipatic fungal proteins Hydrophobins as a plausible candidate to modulate the biomaterial interface. In particular, we will investigate class I hydrophobin extracted from the basidiomycete fungus Pleurotus ostreatus, whose properties are only partially investigated. Several studies have shown that class I hydrophobins do not seem to be toxic or cytotoxic or immunogenic, thus they are susceptible to be used in various medical and technical applications. We propose to coat model surfaces with thin layers of native hydrophobin. The adhesion properties of the layer to the substrate as well as the wetting properties of the biofilm surfaces, will be fully investigated. Subsequently interaction of bacteria with hydrophobin coated surfaces will be investigated. The goal is to obtain information about the factors that may reduce the incidence of infections due to bacterial colonization on biomaterials.'