NANOSENSOMACH

Nanoengineered Nanoparticles and Quantum Dots for Sensor and Machinery Applications

Coordinatore	THE HEBREW UNIVERSITY OF JERUSALEM.    more Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.
Nazionalità Coordinatore	Israel [IL]
Totale costo	2˙167˙400 €
EC contributo	2˙167˙400 €
Programma	FP7-IDEAS-ERC Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	ERC-2010-AdG_20100224
Funding Scheme	ERC-AG
Anno di inizio	2011
Periodo (anno-mese-giorno)	2011-01-01   -   2016-12-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	THE HEBREW UNIVERSITY OF JERUSALEM.  Organization address address: GIVAT RAM CAMPUS city: JERUSALEM postcode: 91904 contact info Titolo: Mr. Nome: Hani Cognome: Ben-Yehuda Email: send email Telefono: +972 2 6586676 Fax: +972 2 6513205	IL (JERUSALEM)	hostInstitution	2˙167˙400.00
2	THE HEBREW UNIVERSITY OF JERUSALEM.  Organization address address: GIVAT RAM CAMPUS city: JERUSALEM postcode: 91904 contact info Titolo: Prof. Nome: Itamar Cognome: Willner Email: send email Telefono: +972 2 6585272 Fax: +972 2 6527715	IL (JERUSALEM)	hostInstitution	2˙167˙400.00

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 Obiettivo del progetto (Objective)

'Chemically modified metallic nanoparticles (NPs) or semiconductor quantum dots (QDs) are central components for the future development of nanotechnology and nanobiotechnology. This program aims to introduce new dimensions into the field of nanotechnology and nanobiotechnology by synthesizing, characterizing and assembling molecule- or biomolecule-modified nanoparticles (NPs)/Quantum dots (QDs) hybrid nanostructures that perform tailored and programmable functionalities. The project will include two complementary research activities. One direction will include the generation of electropolymerized ligand-functionalized Au NPs matrices on electrode surfaces. By tethering of appropriate ligands to the NPs, imprinted matrices for selective sensing, and signal-triggered NPs 'sponges' for the selective uptake and release of substrates will be designed. Also, electrochemically induced pH changes by the NPs matrices will be used to control chemical reactivity (e.g., sol-gel transitions, activation of the ATP synthase machinery). The second research direction will implement ligand-modified QDs for the sensing of ions or molecular substrates. Similarly, nucleic acid-functionalized QDs will be used to develop new versatile sensing platforms exhibiting multiplexed analysis capabilities. One platform will include the quenching of the QDs by G-quadruplexes, whereas the second platform will use biochemiluminescence resonance energy transfer (BRET) as readout signal. Also, QDs-modified supramolecular DNA nanostructures will be designed to perform programmed machinery functions such as 'bi-pedal walker', 'seesaw', 'gear' or 'tweezers', and the machinery functions will be transduced by the optical properties of the QDs. Finally, DNA-machines that trigger the isothermal amplified replication of the analyzed nucleic acid will be designed, and QDs tethered to the machine will optically transduce the replication process at real-time.'