CHEMBIOLPBINT
Chemical biology of natural products in plant-bacteria interactions
| Coordinatore | UNIVERSITAET DUISBURG-ESSEN
Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie. |
| Nazionalità Coordinatore | Germany [DE] |
| Totale costo | 1˙490˙900 € |
| EC contributo | 1˙490˙900 € |
| Programma | FP7-IDEAS-ERC
Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) |
| Code Call | ERC-2010-StG_20091028 |
| Funding Scheme | ERC-SG |
| Anno di inizio | 2011 |
| Periodo (anno-mese-giorno) | 2011-03-01 - 2016-02-29 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
UNIVERSITAET DUISBURG-ESSEN
Organization address
address: UNIVERSITAETSSTRASSE 2 contact info |
DE (ESSEN) | hostInstitution | 1˙490˙900.00 |
| 2 |
UNIVERSITAET DUISBURG-ESSEN
Organization address
address: UNIVERSITAETSSTRASSE 2 contact info |
DE (ESSEN) | hostInstitution | 1˙490˙900.00 |
Mappa
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Obiettivo del progetto (Objective)
'This project deals with the elucidation of the biological role of natural products in plant-bacteria interactions. Plant-associated bacteria synthesize a vast number of biologically active natural products that modulate the physiology and functioning of their host plants. For example, plant pathogens often cause devastating crop losses by secreting low molecular weight phytotoxins, while some symbiotic bacteria biosynthesize plant-protecting compounds that assist in lowering biotic and abiotic plant stresses. It is therefore surprising that although natural products seem to play key roles in the complex interaction network between bacteria and plants, most of their biological functions and molecular targets are still unknown. To date, almost all studies on plant-bacteria interactions have been performed with biological approaches. Here, we propose to investigate the biological role of plant-associated natural products with the aid of a chemistry-driven approach, relying on the power of chemical synthesis to i) generate these natural products and/or suitable natural product derivatives, ii) to elucidate their targets in plants, and iii) to apply them in plant-bacteria studies. Although natural products have long been in the focus of chemical research, such a systematic chemistry-driven approach has, to our knowledge, never been performed before in plant-bacteria interactions. Our project will therefore not only serve to i) decipher basic research questions and ii) identify potential lead structures for agricultural and medicinal applications, but will also contribute to iii) the refinement of chemical syntheses strategies, iv) the advancement of target finding approaches and v) the establishment of chemical biology approaches in plant biology.'