DISC1 & AXOGENESIS

In vivo analysis of DISC1 function in synaptogenesis and axonal transport

Coordinatore	INSTITUT CURIE    more  Organization address address: 26, rue d'Ulm city: PARIS postcode: 75248 contact info Titolo: Ms. Nome: Corinne Cognome: Cumin Email: send email Telefono: +33 1 56 24 66 20 Fax: 33156246627
Nazionalità Coordinatore	France [FR]
Totale costo	100˙000 €
EC contributo	100˙000 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2010-RG
Funding Scheme	MC-IRG
Anno di inizio	2011
Periodo (anno-mese-giorno)	2011-04-01   -   2015-03-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	INSTITUT CURIE  Organization address address: 26, rue d'Ulm city: PARIS postcode: 75248 contact info Titolo: Ms. Nome: Corinne Cognome: Cumin Email: send email Telefono: +33 1 56 24 66 20 Fax: 33156246627	FR (PARIS)	coordinator	100˙000.00

Mappa

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 Obiettivo del progetto (Objective)

'Schizophrenia is a highly hereditable psychological disease that affects up to 1% of the world population. This pathology causes devastating neurological symptoms. A great advance in understanding the basic biological processes affected in schizophrenia came from the discovery of some of the genes that when mutated represent a risk factor for the development of the disease, most likely acting in combination among each other and with environmental factors. One of the best established of these susceptibility genes is a called Disrupted-in-schizophrenia-1 (DISC1). DISC1 has been implicated in many fundamental process and it likely to perform many tasks during the normal development and function of neurons. I am proposing to investigate the involvement of DISC1 in the transport of cargoes along the neuronal axon. This phenomenon is of crucial importance for normal brain function since it allows the trafficking of proteins and organelles between the cell body of the neurons and the synapses at the periphery, and vice versa. There are indications that DISC1 may be regulating this bidirectional transport by interacting with microtubule associated motors and that this process may be altered in schizophrenic patients. Using zebrafish I will be able to observe this phenomenon in vivo, with a detail resolution that is not possible in humans or other mammals. Using a combination of experimental tools including, zebrafish mutants for the DISC1 locus, dominant negative approaches and shRNA knock down, I will assay the function of DISC1 in single neurons separating its later role in neuronal function from early ones. The brain of zebrafish larvae is in fact transparent and small enough to allow the direct observations of fluorescent proteins in single axons. Furthermore, these dynamic processes are highly conserved between fish and humans and what we learn from the fish model will tell us more about DISC1 function in humans as well.'

Introduzione (Teaser)

A European research study is using zebrafish to shed light onto the molecular determinants of schizophrenia.