S-DODGR

Structure and dynamics of desensitization in glutamate receptors

Coordinatore	FORSCHUNGSVERBUND BERLIN E.V.    more  Organization address address: Rudower Chaussee 17 city: BERLIN postcode: 12489 contact info Titolo: Dr. Nome: Anne Cognome: Höner Email: send email Telefono: +49 30 94793286 Fax: +49 30 94793109
Nazionalità Coordinatore	Germany [DE]
Totale costo	163˙242 €
EC contributo	163˙242 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2010-IIF
Funding Scheme	MC-IIF
Anno di inizio	2011
Periodo (anno-mese-giorno)	2011-04-01   -   2011-06-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	FORSCHUNGSVERBUND BERLIN E.V.  Organization address address: Rudower Chaussee 17 city: BERLIN postcode: 12489 contact info Titolo: Dr. Nome: Anne Cognome: Höner Email: send email Telefono: +49 30 94793286 Fax: +49 30 94793109	DE (BERLIN)	coordinator	163˙242.40

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 Obiettivo del progetto (Objective)

'AMPA and kainate receptors mediate fast excitatory synaptic transmission. AMPA receptor ligand-binding domains form dimers, which are well-known to control ion channel activation and desensitization. The dimer stability is related to the rate and extent of desensitization. Despite the similarity in structure between AMPA and kainate receptors, they present a clear difference in function, suggesting that specific interactions governing gating differ between these two subtypes. In this application we propose a series of chemical, electrophysiological and structural experiments to find the structural determinants of desensitization on AMPA and kainate receptors. Based on hypotheses of the tetrameric arrangements of subunits, we will insert reactive amino acids in key sites on the channels. Using a unique multi barrel fast perfusion system, we will trap receptors in different configurations using transition metal bridges or disulphide bonds, to map the interactions between dimers and determine the conformational differences between these two receptors.'