MULTIFUN
Multifunctional Nanotechnology for selective detection and Treatment of cancer
| Coordinatore | ATOS SPAIN SA
Organization address
address: Calle Albarracin 25 contact info |
| Nazionalità Coordinatore | Spain [ES] |
| Totale costo | 13˙150˙553 € |
| EC contributo | 9˙799˙994 € |
| Programma | FP7-NMP
Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies |
| Code Call | FP7-NMP-2010-LARGE-4 |
| Funding Scheme | CP-IP |
| Anno di inizio | 2011 |
| Periodo (anno-mese-giorno) | 2011-06-13 - 2015-06-12 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
ATOS SPAIN SA
Organization address
address: Calle Albarracin 25 contact info |
ES (Madrid) | coordinator | 810˙390.00 |
| 2 |
AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Organization address
address: CALLE SERRANO 117 contact info |
ES (MADRID) | participant | 1˙213˙573.00 |
| 3 |
THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
Organization address
address: College Green - contact info |
IE (DUBLIN) | participant | 1˙059˙807.00 |
| 4 |
Nome Ente NON disponibile
Organization address
city: Jena contact info |
DE (Jena) | participant | 1˙003˙160.00 |
| 5 |
FUNDACION IMDEA NANOCIENCIA
Organization address
address: "CIUDAD UNIVERSITARIA CANTOBLANCO MODCIX, AVDA FRANCISCO TOMAS Y VALIENTE 7" contact info |
ES (MADRID) | participant | 875˙680.00 |
| 6 |
THE UNIVERSITY OF MANCHESTER
Organization address
address: OXFORD ROAD contact info |
UK (MANCHESTER) | participant | 838˙107.00 |
| 7 |
KING'S COLLEGE LONDON
Organization address
address: Strand contact info |
UK (LONDON) | participant | 571˙937.00 |
| 8 |
INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE TOULOUSE INSAT
Organization address
address: AVENUE DE RANGUEIL 135 contact info |
FR (TOULOUSE) | participant | 518˙020.00 |
| 9 |
PEPRIC NV
Organization address
address: KAPELDREEF 75 contact info |
BE (LEUVEN) | participant | 496˙148.00 |
| 10 |
FYZIKALNI USTAV AV CR V.V.I
Organization address
address: NA SLOVANCE 2 contact info |
CZ (PRAHA 8) | participant | 449˙999.00 |
| 11 |
FUNDACION CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III
Organization address
address: CALLE MELCHOR FERNANDEZ ALMAGRO 3 contact info |
ES (MADRID) | participant | 445˙919.52 |
| 12 |
LIQUIDS RESEARCH LTD
Organization address
address: DEINIOL ROAD UNIT 3B MENTEC contact info |
UK (BANGOR) | participant | 402˙823.00 |
| 13 |
UNIVERSITE PARIS XII VAL DE MARNE
Organization address
address: AVENUE DU GENERAL DE GAULLE 61 contact info |
FR (CRETEIL) | participant | 321˙050.00 |
| 14 |
UNIVERSITY COLLEGE CORK, NATIONAL UNIVERSITY OF IRELAND, CORK
Organization address
address: Western Road contact info |
IE (CORK) | participant | 298˙972.00 |
| 15 |
QUEEN MARY UNIVERSITY OF LONDON
Organization address
address: 327 MILE END ROAD contact info |
UK (LONDON) | participant | 274˙496.48 |
| 16 |
"PHARMAMAR, S.A.U."
Organization address
address: "Avda. de los Reyes , Poligono Industrial La Mina 1" contact info |
ES (COLMENAR VIEJO (MADRID)) | participant | 219˙912.00 |
| 17 |
SOLUCIONES NANOTCNOLOGICAS SL
Organization address
address: POLIGONO INDUSTRIAL EL ZAFRANAR contact info |
ES (ZARAGOZA) | participant | 0.00 |
Mappa
Word cloud
Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.
Obiettivo del progetto (Objective)
'The aim of the MultiFun consortium is to develop and validate a novel and minimally-invasive nanotechnology system to improve cancer diagnosis and treatment. MultiFun nanotechnology is based on multifunctionalised magnetic nanoparticles to selectively target and eliminate breast and pancreatic cancer (stem) cells. The improved magnetic features of the MultiFun magnetic nanoparticles will lead to potential medical applications such as contrast agents and magnetic heating inductors. Moreover, magnetic nanoparticles can be functionalised with ligands to increase their affinity towards cancer cells in order to facilitate diagnosis of tumours by MRI. Targeting peptides and antibodies will be employed, including antibodies against cancer stem cells leading to early cancer detection by MRI means. The same nanoparticles will be used simultaneously as functional nanocarriers and heating inductors in order to provide a combined therapeutic modality. The synergistic effects of drugs, peptides, small RNAs and heat will be evaluated to determine the effectiveness of different therapeutic combinations. Interestingly, the use of ligands will favour the specific application of the therapeutic modalities to cancer (stem) cells, increasing the effectiveness and reducing side effects. Thus, MultiFun multimodal therapeutic approach is designed to efficiently remove cancer cells, including cancer stem cells, from the tumour site. The toxicity of functionalised magnetic nanoparticles will be assessed in vitro and in vivo to warrant a safe use and shed some light on the risks. The distribution and activity evaluation of functionalised nanoparticles will be performed in human breast and pancreatic cancer xenograft models. The use of novel magnetic nanoparticles for biomedical applications provides opportunities for new instrumentation: 1) detection and quantification of magnetic nanoparticles in blood, urine and tissues, and 2) magnetic heating induction for raising cell temperature.'
Introduzione (Teaser)
Nanoparticle-based therapeutic applications have gained increased attention in recent years. This has led to the development of a great variety of different, sophisticated and multifunctional nanoparticle formulations.