MOLREGNEUROGEN

Characterisation of molecules regulating adult hippocampal neurogenesis

Coordinatore	TECHNISCHE UNIVERSITAET DRESDEN    more  Organization address address: HELMHOLTZSTRASSE 10 city: DRESDEN postcode: 1069 contact info Titolo: Mrs. Nome: Beate Cognome: Brenner Email: send email Telefono: +49 351 463 42185 Fax: +49 351 463 39742
Nazionalità Coordinatore	Germany [DE]
Totale costo	226˙945 €
EC contributo	226˙945 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2010-IIF
Funding Scheme	MC-IIF
Anno di inizio	2011
Periodo (anno-mese-giorno)	2011-04-01   -   2013-03-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	TECHNISCHE UNIVERSITAET DRESDEN  Organization address address: HELMHOLTZSTRASSE 10 city: DRESDEN postcode: 1069 contact info Titolo: Mrs. Nome: Beate Cognome: Brenner Email: send email Telefono: +49 351 463 42185 Fax: +49 351 463 39742	DE (DRESDEN)	coordinator	226˙945.00

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 Obiettivo del progetto (Objective)

'The hippocampus contains a population of stem cells that continually proliferate to produce new neurons. The development of new markers capable of identifying and isolating defined neural stem cell populations are of utmost importance. Prominin-1 has successfully been used as a marker for the isolation of neural stem and progenitor cells from other brain regions including the mouse embryonic forebrain, the adult SVZ and the postnatal cerebellum. However, its potential as a marker of stem cells in the adult hippocampus remains to be confirmed. The first aim of this proposal is to examine the efficacy of Prominin-1 as a potential marker for the isolation and characterisation of hippocampal stem cells. We have recently discovered a dormant or latent population of neural precursors in the adult hippocampus that can be triggered to generate new neurons. Identification and characterisation of the molecules that trigger these latent neural precursors to generate new neurons should lead to the development of radical new therapies to treat neurodegenerative conditions that affect the hippocampus. Two candidate molecules (Prominin-2 and AP2-gamma) have been chosen based on preliminary microarray data and will be examined for their ability stimulate hippocampal neurogenesis.'