IF INTERACTIONS

"Self-Assembly, Structures and Interactions of Cell Specific Cytoskeleton"

Coordinatore	TEL AVIV UNIVERSITY    more  Organization address address: RAMAT AVIV city: TEL AVIV postcode: 69978 contact info Titolo: Ms. Nome: Lea Cognome: Pais Email: send email Telefono: 97236408477 Fax: 97236408477
Nazionalità Coordinatore	Israel [IL]
Totale costo	100˙000 €
EC contributo	100˙000 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2011-CIG
Funding Scheme	MC-CIG
Anno di inizio	2011
Periodo (anno-mese-giorno)	2011-08-01   -   2015-07-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	TEL AVIV UNIVERSITY  Organization address address: RAMAT AVIV city: TEL AVIV postcode: 69978 contact info Titolo: Ms. Nome: Lea Cognome: Pais Email: send email Telefono: 97236408477 Fax: 97236408477	IL (TEL AVIV)	coordinator	100˙000.00

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 Obiettivo del progetto (Objective)

'Cell specificity plays a critical role in the complexity high-order organism can achieve. The cascade of signals and events leading embryonic stem-cells to differentiate has been a major research topic in the last century. During differentiation, cell-specific proteins are expressed in order to accommodate the necessary specific functions. Among other cell/tissue specific modulations, the cytoskeleton is altered during differentiation and at different developmental stages of a specific cell type. This is presumably to account for the constantly-changing mechanical strains and stresses, as well as interactions with the environment, intracellular transport and cell motility. We propose to study a class of cytoskeleton proteins, named intermediate filaments, which are expressed at various developmental stages and cell/tissue types of neuro-muscular origin. Interdisciplinary studies will include protein purification, biochemical characterization, high-resolution microscopy, as well as structural studies in hydrated state using small-angle x-ray scattering. Combining these multiple techniques, we aim to model and reveal how minor molecular differences between proteins from the intermediate filament family are translated into supramolecular forces that, in turn, alter the cytoskeleton elastic and mechanical properties.'