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ULTRADIAN SIGNED

Dynamic hormone diagnostics

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 ULTRADIAN project word cloud

Explore the words cloud of the ULTRADIAN project. It provides you a very rough idea of what is the project "ULTRADIAN" about.

mass    points    always    healthy    single    conventional    dynamic    impractical    simplified    liquid    revolutionize    72    replacing    limited    lcmsms    tends    poses    hours    sampling    collector    proximity    time    tandem    hurdles    ms    demonstration    vs    hormonomes    person    commercial    disorders    patterns    academic    treatment    sensitivity    unprecedented    cycling    producing    patient    diagnostic    detect    hormone    overcome    severely    purposes    lt    generate    analyte    minute    proseek    fractions    assays    markets    absolute    routine    random    life    diagnostics    ambulatory    endocrine    populations    consuming    adrenal    ultradian    collection    diseases    rapid    health    levels    extension    hour    fraction    subcutaneous    lcms    abnormalities    profiling    clinical    timeline    multiplex    six    accompanied    specificity    hormonome    cycle    monitoring    portable    circadian    microdialysate    multiple    pituitary    24    stakeholders    lack    combined    ultrasensitive    daily    care    spectroscopy    validate    chromatography    economisation    setting    losing    secretion   

Project "ULTRADIAN" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITETET I BERGEN 

Organization address
address: MUSEPLASSEN 1
city: BERGEN
postcode: 5020
website: www.uib.no

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Norway [NO]
 Project website http://www.ultradian.eu
 Total cost 5˙999˙381 €
 EC max contribution 5˙999˙381 € (100%)
 Programme 1. H2020-EU.3.1.3. (Treating and managing disease)
 Code Call H2020-PHC-2014-two-stage
 Funding Scheme RIA
 Starting year 2015
 Duration (year-month-day) from 2015-09-01   to  2019-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITETET I BERGEN NO (BERGEN) coordinator 2˙002˙047.00
2    UNIVERSITY OF BRISTOL UK (BRISTOL) participant 1˙221˙521.00
3    KAROLINSKA INSTITUTET SE (STOCKHOLM) participant 938˙307.00
4    PERIFEREIAKO GENIKO NOSOKOMEIO ATHINON EVAGGELISMOS EL (ATHINA) participant 713˙281.00
5    OLINK PROTEOMICS AB SE (UPPSALA) participant 686˙725.00
6    DESIGNWORKS WINDSOR LTD UK (Windsor) participant 437˙500.00
7    MOLECULINK AB SE (UPPSALA) participant 0.00

Map

 Project objective

We propose to revolutionize current endocrine diagnostics by replacing conventional, time-consuming single-analyte hormone assays with ambulatory dynamic endocrine diagnostics. Disorders of the adrenal and pituitary endocrine systems are not only accompanied by changes in absolute hormone levels, but also secretion patterns. The rapid circadian (24 hour) and ultradian (< 24 hour) cycling of hormone levels poses diagnostic challenges since random measurements do not always detect abnormalities. Furthermore, monitoring of treatment of endocrine diseases are often severely limited by lack of multiple measurements at different time points, which is impractical in an out-patient setting.

To overcome these hurdles academic and commercial partners propose to:

• Develop a novel microdialysate sampling and analysis system for adrenal and pituitary hormonome profiling

• Validate the method in healthy vs. six populations with endocrine disorders

• Promote the system for demonstration in routine clinical practice by dissemination of results to relevant European stakeholders The portable fraction collector for subcutaneous microdialysate combined with state-or-the-art ultrasensitive assays by liquid chromatography tandem mass spectroscopy (LCMS/MS) and multiplex proximity extension assays (Proseek), will allow collection of 10 minute fractions for up to 72 hours while the person tends to daily life activities. LCMSMS and Proseek assays can generate a timeline of “hormonomes” covering the 24 hour cycle without losing sensitivity and specificity, producing not only hormone levels, but also secretion patterns for diagnostics and monitoring purposes.

ULTRADIAN will deliver an ambulatory diagnostic system with unprecedented sensitivity and specificity for simplified diagnostics and monitoring of endocrine conditions, economisation of health care, and new products and markets for the European diagnostic sector.

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The information about "ULTRADIAN" are provided by the European Opendata Portal: CORDIS opendata.

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