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INTEGRATE SIGNED

Interdisciplinary Training Network for Validation of Gram-Negative Antibacterial Targets

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

INTEGRATE project word cloud

Explore the words cloud of the INTEGRATE project. It provides you a very rough idea of what is the project "INTEGRATE" about.

individual reverse disciplines inter innovative team human vitro mesh exposure designed mechanisms academic intention posing gram infections ranging seamlessly alternatives cooperation treatment fitness reducing 15 mutual direct discovery technologies accomplished synthesis vivo global submitted organic host form antimicrobials beneficiaries biology parliament training validation committed rising report bacterial silico 11 students immune events stage recommendation antimicrobial eight resistance fragmentation threats council negative biochemistry thereby coupled screening action esrs networking encompassing platform secondment integrate molecular preclinical latest identification sectors threat compound antibacterial plan framework mode agents contributions 2011 exposed assembled pathogen gene health clearance animal series

Project "INTEGRATE" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITA DEGLI STUDI DI PARMA Organization address address: VIA UNIVERSITA 12 city: PARMA postcode: 43100 website: www.unipr.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Italy [IT]
Project website	http://www.integrate.fi
Total cost	2˙793˙330 €
EC max contribution	2˙793˙330 € (100%)
Programme	1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
Code Call	H2020-MSCA-ITN-2014
Funding Scheme	MSCA-ITN-ETN
Starting year	2015
Duration (year-month-day)	from 2015-01-01 to 2018-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITA DEGLI STUDI DI PARMA UNIVERSITA DEGLI STUDI DI PARMA Organization address address: VIA UNIVERSITA 12 city: PARMA postcode: 43100 website: www.unipr.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (PARMA)	coordinator	516˙122.00
2	THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE Organization address address: TRINITY LANE THE OLD SCHOOLS city: CAMBRIDGE postcode: CB2 1TN website: www.cam.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CAMBRIDGE)	participant	273˙287.00
3	HELSINGIN YLIOPISTO HELSINGIN YLIOPISTO Organization address address: YLIOPISTONKATU 3 city: HELSINGIN YLIOPISTO postcode: 14 website: www.helsinki.fi contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FI (HELSINGIN YLIOPISTO)	participant	269˙145.00
4	ITA-SUOMEN YLIOPISTO ITA-SUOMEN YLIOPISTO Organization address address: YLIOPISTONRANTA 1 E city: KUOPIO postcode: 70211 website: www.uef.fi contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FI (KUOPIO)	participant	269˙145.00
5	APTUIT (VERONA) SRL APTUIT (VERONA) SRL Organization address address: VIA ALESSANDRO FLEMING 4 city: VERONA postcode: 37135 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (VERONA)	participant	258˙061.00
6	UNIVERSITEIT ANTWERPEN UNIVERSITEIT ANTWERPEN Organization address address: PRINSSTRAAT 13 city: ANTWERPEN postcode: 2000 website: www.ua.ac.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (ANTWERPEN)	participant	250˙560.00
7	FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V. FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V. Organization address address: HANSASTRASSE 27C city: MUNCHEN postcode: 80686 website: www.fraunhofer.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUNCHEN)	participant	249˙216.00
8	TAROS CHEMICALS GMBH & CO KG TAROS CHEMICALS GMBH & CO KG Organization address address: Emil-Figge-Str. 76A city: Dortmund postcode: 44227 website: www.taros.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (Dortmund)	participant	249˙216.00
9	UNIVERZA V LJUBLJANI UNIVERZA V LJUBLJANI Organization address address: KONGRESNI TRG 12 city: LJUBLJANA postcode: 1000 website: http://www.uni-lj.si contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SI (LJUBLJANA)	participant	234˙997.00
10	LATVIJAS ORGANISKAS SINTEZES INSTITUTS LATVIJAS ORGANISKAS SINTEZES INSTITUTS Organization address address: AIZKRAUKLES 21 city: RIGA postcode: 1006 website: www.osi.lv contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	LV (RIGA)	participant	223˙577.00
11	CSC-TIETEEN TIETOTEKNIIKAN KESKUS OY CSC-TIETEEN TIETOTEKNIIKAN KESKUS OY Organization address address: Keilaranta 14 city: ESPOO postcode: 2101 website: www.csc.fi contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FI (ESPOO)	partner	0.00
12	Finnish Patent Office and Registration Finnish Patent Office and Registration Organization address address: Arkadiankatu 6 A city: Helsinki postcode: 101 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FI (Helsinki)	partner	0.00
13	Matera, Lda Matera, Lda Organization address address: PARQUE TECNOLOGICO DE CANTANHEDE city: Cantanhede postcode: 3060-197 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PT (Cantanhede)	partner	0.00
14	TTY-SAATIO TTY-SAATIO Organization address address: KORKEAKOULUNKATU 10 city: TAMPERE postcode: 33720 website: www.tut.fi contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FI (TAMPERE)	partner	0.00

Map

Project objective

Antimicrobial resistance is posing a continuously-rising threat to global health. Indeed, one key recommendation from the recent “Action plan against the rising threats from Antimicrobial Resistance” report (submitted by the Commission to the European Parliament and Council (15.11.2011)) is the development of effective antimicrobials or alternatives for treatment of human and animal infections. The INTEGRATE project is a direct response to this. We have assembled a team of 10 beneficiaries from eight EU member states, encompassing both academic and non-academic sectors and different disciplines, to form a consortium committed to training Early Stage Researchers (ESRs) in the discovery and preclinical validation of novel Gram-negative antibacterial agents and antibacterial targets. The principle aim of the consortium is to provide a training platform where students are exposed to every aspect of the antimicrobial discovery process, ranging from target identification and validation, through organic synthesis, in silico design and compound screening, to mode-of-action and possible resistance mechanisms. This exposure will be accomplished through a concrete secondment plan, coupled with a series of high-level consortium-wide training events and networking programmes. Our intention is to reverse the current fragmentation of approaches towards antibacterial discovery through mutual cooperation. The INTEGRATE training framework is built on an innovative research project aimed at targeting important but non-essential gene products as an effective means of reducing bacterial fitness, thereby facilitating clearance of the pathogen by the host immune system. To achieve this, the individual work programmes have been designed to seamlessly inter-mesh contributions from the fields of in silico design, organic synthesis, molecular biology and biochemistry, and the very latest in vitro and in vivo screening technologies.

Deliverables

List of deliverables.
Kick-off Meeting	Other	2020-02-06 16:17:21
ESR recruitments	Other	2020-02-06 16:17:21
SAB	Other	2020-02-06 16:17:21
Website	Websites, patent fillings, videos etc.	2020-02-06 16:17:21
PCDPs	Other	2020-02-06 16:17:21
Gender Equality in Science Course	Other	2020-02-06 16:17:21
Short course	Other	2020-02-06 16:17:21

Take a look to the deliverables list in detail: detailed list of INTEGRATE deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2017	Alyssa McVey, Sean Bartlett and Martin Welch Targeting the glyoxylate shunt for antibacterial intervention in Pseudomonas aeruginosa published pages: , ISSN: , DOI:		2020-02-06
2017	Alyssa McVey, Sean Bartlett, Martin Welch Structural and functional characterisation of the glyoxylate shunt enzymes from Pseudomonas aeruginosa - ORAL CONFERENCE TALK published pages: , ISSN: , DOI:		2020-02-06
2017	Alyssa C. McVey, Prasanthi Medarametla, Xavier Chee, Sean Bartlett, Antti Poso, David R. Spring, Taufiq Rahman, Martin Welch Structural and Functional Characterization of Malate Synthase G from Opportunistic Pathogen Pseudomonas aeruginosa published pages: 5539-5549, ISSN: 0006-2960, DOI: 10.1021/acs.biochem.7b00852	Biochemistry 56/41	2020-02-06
2018	Martina Durcik, PÃ¤ivi Tammela, Michaela BaranÄokovÃ¡, Tihomir TomaÅ¡iÄ, Janez IlaÅ¡, Danijel Kikelj, Nace Zidar Synthesis and Evaluation of N -Phenylpyrrolamides as DNA Gyraseâ€…B Inhibitors published pages: 186-198, ISSN: 1860-7179, DOI: 10.1002/cmdc.201700549	ChemMedChem 13/2	2020-02-06
2018	Joana MagalhÃ£es, Giannamaria Annunziato, Nina Franko, Marco Pieroni, Barbara Campanini, Agostino Bruno, Gabriele Costantino Integration of Enhanced Sampling Methods with Saturation Transfer Difference Experiments to Identify Protein Druggable Pockets published pages: 710-723, ISSN: 1549-9596, DOI: 10.1021/acs.jcim.7b00733	Journal of Chemical Information and Modeling 58/3	2020-02-06
2018	Nina Franko, Konstantinos Grammatoglou, Barbara Campanini, Gabriele Costantino, Aigars Jirgensons, Andrea Mozzarelli Inhibition of O -acetylserine sulfhydrylase by fluoroalanine derivatives published pages: 1343-1351, ISSN: 1475-6366, DOI: 10.1080/14756366.2018.1504040	Journal of Enzyme Inhibition and Medicinal Chemistry 33/1	2020-02-06
2018	Prasanthi Medarametla, Viviana Gatta, Tommi Kajander, Tuomo Laitinen, PÃ¤ivi Tammela, Antti Poso Structure-Based Virtual Screening of LsrK Kinase Inhibitors to Target Quorum Sensing published pages: 2400-2407, ISSN: 1860-7179, DOI: 10.1002/cmdc.201800548	ChemMedChem 13/22	2020-02-06
2018	Carlos Moreno-Cinos, Elisa Sassetti, Irene G. Salado, Gesa Witt, Siham Benramdane, Laura Reinhardt, Cristina Durante Cruz, Jurgen Joossens, Pieter Van der Veken, Heike Brotz-Oesterhelt, PÃ¤ivi Tammela, Mathias Winterhalter, Philip Gribbon, BjÃ¶rn WindshÃ¼gel, Koen Augustyns Î±-Amino diphenyl phosphonates as novel inhibitors of Escherichia coli ClpP protease published pages: , ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.8b01466	Journal of Medicinal Chemistry	2020-02-06
2018	Joana MagalhÃ£es, Nina Franko, Giannamaria Annunziato, Marco Pieroni, Roberto Benoni, Anna Nikitjuka, Andrea Mozzarelli, Stefano Bettati, Anna Karawajczyk, Aigars Jirgensons, Barbara Campanini, Gabriele Costantino Refining the structureâˆ’activity relationships of 2-phenylcyclopropane carboxylic acids as inhibitors of O-acetylserine sulfhydrylase isoforms published pages: 31-43, ISSN: 1475-6366, DOI: 10.1080/14756366.2018.1518959	Journal of Enzyme Inhibition and Medicinal Chemistry 34/1	2020-02-06
2018	Silvia Stotani, Viviana Gatta, Federico Medda, Mohan Padmanaban, Anna Karawajczyk, PÃ¤ivi Tammela, Fabrizio Giordanetto, Dimitrios Tzalis, Simona Collina A Versatile Strategy for the Synthesis of 4,5-Dihydroxy-2,3-Pentanedione (DPD) and Related Compounds as Potential Modulators of Bacterial Quorum Sensing published pages: 2545, ISSN: 1420-3049, DOI: 10.3390/molecules23102545	Molecules 23/10	2020-02-06
2018	Tihomir TomaÅ¡iÄ, Michaela BaranÄokovÃ¡, Nace Zidar, Janez IlaÅ¡, PÃ¤ivi Tammela, Danijel Kikelj Design, synthesis, and biological evaluation of 1-ethyl-3-(thiazol-2-yl)urea derivatives as Escherichia coli DNA gyrase inhibitors published pages: 1700333, ISSN: 0365-6233, DOI: 10.1002/ardp.201700333	Archiv der Pharmazie 351/1	2020-02-06
2016	Silvia Stotani, Christoph Lorenz, Matthias Winkler, Federico Medda, Edwige Picazo, Raquel Ortega Martinez, Anna Karawajczyk, Jorge Sanchez-Quesada, Fabrizio Giordanetto Design and Synthesis of Fsp 3 -Rich, Bis-Spirocyclic-Based Compound Libraries for Biological Screening published pages: 330-336, ISSN: 2156-8952, DOI: 10.1021/acscombsci.6b00005	ACS Combinatorial Science 18/6	2020-02-06
2018	Joana MagalhÃ£es, Nina Franko, Giannamaria Annunziato, Martin Welch, Stephen K. Dolan, Agostino Bruno, Andrea Mozzarelli, Stefano Armao, Aigars Jirgensons, Marco Pieroni, Gabriele Costantino, Barbara Campanini Discovery of novel fragments inhibiting O-acetylserine sulphhydrylase by combining scaffold hopping and ligandâ€“based drug design published pages: 1444-1452, ISSN: 1475-6366, DOI: 10.1080/14756366.2018.1512596	Journal of Enzyme Inhibition and Medicinal Chemistry 33/1	2020-02-06
2017	Å½iga Jakopin, Janez IlaÅ¡, Michaela BaranÄokovÃ¡, MatjaÅ¾ Brvar, PÃ¤ivi Tammela, Marija Sollner Dolenc, Tihomir TomaÅ¡iÄ, Danijel Kikelj Discovery of substituted oxadiazoles as a novel scaffold for DNA gyrase inhibitors published pages: 171-184, ISSN: 0223-5234, DOI: 10.1016/j.ejmech.2017.02.046	European Journal of Medicinal Chemistry 130	2020-02-06
2018	Michaela BaranÄokovÃ¡, Danijel Kikelj, Janez IlaÅ¡ Recent progress in the discovery and development of DNA gyrase B inhibitors published pages: 1207-1227, ISSN: 1756-8919, DOI: 10.4155/fmc-2017-0257	Future Medicinal Chemistry 10/10	2020-02-06
2016	Michaela BaranÄokovÃ¡, Janez IlaÅ¡, Marina Gjorgjieva, Tihomir TomaÅ¡iÄ, PÃ¤ivi Tammela, Vanesa Garrido, Antonio Felici, and Danijel Kikelj Discovery of novel Gyrase B and GyraseB/Topoisomerase IV (ParE) dual Inhibitors with in vitro antibacterial activity published pages: , ISSN: , DOI:		2020-02-06
2016	Gjorgjieva M1, TomaÅ¡iÄ T1, BaranÄokova M1, Katsamakas S1,2, IlaÅ¡ J1, Tammela P3, Peterlin MaÅ¡iÄ L1, Kikelj D1. Discovery of Benzothiazole Scaffold-Based DNA Gyrase B Inhibitors published pages: 8941-8954, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.6b00864	Journal of Medicinal Chemistry Vol. 59, iss. 19 (2016)	2020-02-06
2017	A Felici, M Antolini, M. Negri, V. Garrido Estevez, R Zahler, L Rahme, M Pucci, Aldo Feriani, and Daniele Andreotti Design, synthesis and in vitro profiling of novel inhibitors of Pseudomonas aeruginosa MvfR published pages: , ISSN: , DOI:		2020-02-06
2016	Joana MagalhÃ£es, Giannamaria Annunziato, Marco Pieroni, Nina Franko, Barbara Campanini, Andrea Mozzarelli, Vanesa Estevez, Antonio Felici, and Gabriele Costantino Enzyme inhibition as a new strategy to overcome Multidrug Resistant Bacteria published pages: , ISSN: , DOI:		2020-02-06
2016	Giannamaria Annunziato, Marco Pieroni, Roberto Benoni, Barbara Campanini, Thelma A. Pertinhez, Chiara Pecchini, Agostino Bruno, Joana MagalhÃ£es, Stefano Bettati, Nina Franko, Andrea Mozzarelli, Gabriele Costantino Cyclopropane-1,2-dicarboxylic acids as new tools for the biophysical investigation of O -acetylserine sulfhydrylases by fluorimetric methods and saturation transfer difference (STD) NMR published pages: 78-87, ISSN: 1475-6366, DOI: 10.1080/14756366.2016.1218486	Journal of Enzyme Inhibition and Medicinal Chemistry 31/sup4	2020-02-06
2017	TomaÅ¡iÄ T1, Mirt M2, BaranÄokovÃ¡ M2, IlaÅ¡ J2, Zidar N2, Tammela P3, Kikelj D2 Design, synthesis and biological evaluation of 4,5-dibromo-N-(thiazol-2-yl)-1H-pyrrole-2-carboxamide derivatives as novel DNA gyrase inhibitors. published pages: 338-349, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2016.10.038	Bioorganic & Medicinal Chemistry Vol. 25, Iss. 1 (2017)	2020-02-06

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