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RAIS

Scalable, point-of-care and label free microarray platform for rapid detection of Sepsis

Total Cost €

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EC-Contrib. €

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Partnership

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Outcomes and
results

RAIS project word cloud

Explore the words cloud of the RAIS project. It provides you a very rough idea of what is the project "RAIS" about.

biomarkers detection bio mobile ket reader microarray interferometric invasive accurate hospital consequence microliters pg biophotonics covered markers life battery outcomes treatment proximity structured diagnosis point nano right mortality platform powered minimally free sensing perfectly bills care proper tests minutes micro rais levels disruptive combining receptors put rate fast few ccd line insurance screening health acute measuring plate critical sepsis ict consisting capture cmos quantifying cartridge transparent acids ultimately 2014 simultaneously image samples concentration detect ml ribonucleic integration area 70 individuals microfluidic proteins savings changing interleukins photonics sensitivity reducing device billion patient lower technique uses arrays patients translate portable shorter stays geometry slide optical serum proprietary million blood potentially drugs micrornas diseases market microscopy label surface unnecessary validate lens

Project "RAIS" data sheet

The following table provides information about the project.

Coordinator	FUNDACIO INSTITUT DE CIENCIES FOTONIQUES Organization address address: AVINGUDA CARL FRIEDRICH GAUSS 3 city: Castelldefels postcode: 8860 website: www.icfo.eu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Spain [ES]
Project website	http://www.rais-project.eu
Total cost	3˙388˙572 €
EC max contribution	2˙988˙572 € (88%)
Programme	1. H2020-EU.2.1.1.6. (Micro- and nanoelectronics and photonics: Key enabling technologies related to micro- and nanoelectronics and to photonics, covering also quantum technologies)
Code Call	H2020-ICT-2014-1
Funding Scheme	RIA
Starting year	2015
Duration (year-month-day)	from 2015-01-01 to 2018-03-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	FUNDACIO INSTITUT DE CIENCIES FOTONIQUES FUNDACIO INSTITUT DE CIENCIES FOTONIQUES Organization address address: AVINGUDA CARL FRIEDRICH GAUSS 3 city: Castelldefels postcode: 8860 website: www.icfo.eu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (Castelldefels)	coordinator	812˙945.00
2	TRINEAN NV TRINEAN NV Organization address address: DULLE GRIETLAAN 17/3 city: GENTBRUGGE postcode: 9050 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (GENTBRUGGE)	participant	416˙660.00
3	FUNDACIO HOSPITAL UNIVERSITARI VALL D'HEBRON - INSTITUT DE RECERCA FUNDACIO HOSPITAL UNIVERSITARI VALL D'HEBRON - INSTITUT DE RECERCA Organization address address: PASSEIG VALL D HEBRON 119-129 EDIFICIO DE RECERCA city: BARCELONA postcode: 8035 website: http://www.vhir.org/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (BARCELONA)	participant	370˙358.00
4	MICROTEC GESELLSCHAFT FUR MIKROTECHNOLOGIE MBH MICROTEC GESELLSCHAFT FUR MIKROTECHNOLOGIE MBH Organization address address: BISMARCKSTRASSE 142B city: DUISBURG postcode: 47057 website: www.microtec-d.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (DUISBURG)	participant	298˙750.00
5	IXSCIENT LIMITED IXSCIENT LIMITED Organization address address: POPES GROVE 76 city: TWICKENHAM MIDDLESEX postcode: TW1 4JX website: www.ixscient.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (TWICKENHAM MIDDLESEX)	participant	264˙375.00
6	DIESSE DIAGNOSTICA SENESE SPA DIESSE DIAGNOSTICA SENESE SPA Organization address address: VIA SOLARI 19 city: MILANO postcode: 20144 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (MILANO)	participant	250˙450.00
7	FUNDACIO INSTITUT CATALA DE NANOCIENCIA I NANOTECNOLOGIA FUNDACIO INSTITUT CATALA DE NANOCIENCIA I NANOTECNOLOGIA Organization address address: CAMPUS DE LA UAB EDIFICI Q ICN2 city: BELLATERRA (BARCELONA) postcode: 8193 website: www.icn.cat contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (BELLATERRA (BARCELONA))	participant	246˙406.00
8	AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS Organization address address: CALLE SERRANO 117 city: MADRID postcode: 28006 website: http://www.csic.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (MADRID)	participant	153˙736.00
9	BRAHMS GMBH BRAHMS GMBH Organization address address: NEUENDORFSTRASSE 25 city: HENNIGSDORF postcode: 16761 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (HENNIGSDORF)	participant	144˙000.00
10	INSTITUT CATALA DE LA SALUT INSTITUT CATALA DE LA SALUT Organization address address: GRAN VIA DE LES CORTS CATALANES 587 city: BARCELONA postcode: 8007 website: http://www.gencat.cat/ics/germanstrias/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (BARCELONA)	participant	30˙891.00
11	ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE Organization address address: BATIMENT CE 3316 STATION 1 city: LAUSANNE postcode: 1015 website: www.epfl.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (LAUSANNE)	participant	0.00

Map

Project objective

The diagnosis and management of acute Sepsis is a critical area where fast and accurate results can translate into life changing health outcomes for individuals. The overall aim of RAIS is to develop a new point-of-care label-free microarray platform and validate it for quantifying levels of specific Sepsis’ biomarkers. The approach uses a novel interferometric technique ultimately capable of providing very large arrays of tests. Specific objectives and activities include: (i) an optical microarray reader based on a disruptive proprietary design combining interferometric lens-free microscopy and proximity CCD or CMOS image sensing; (ii) a microarray plate, in a proper microfluidic cartridge, consisting of a transparent slide with a novel nano-structured surface geometry to increase the detection sensitivity and covered by specific receptors to capture bio-markers; (iii) their integration in a portable and battery powered label free microarray platform potentially capable of measuring more than 1 million bio-targets simultaneously. The developed technology will be capable to detect micro-ribonucleic acids (microRNAs), interleukins and other specific proteins associated to Sepsis using a few microliters of blood or serum samples, in a concentration of a few pg/ml, within 30 minutes (sample to result) and at a cost per patient of less than 50€. In this way, patients will be put on the right treatment more rapidly, potentially reducing the Sepsis mortality rate of more than 70%, with estimated cost savings of more than €10 billion per year as a consequence of shorter hospital stays, reduced use of unnecessary drugs and lower associated insurance bills. The technical approach, targeted device, application and the addressed market sector are perfectly in line with the call H2020-ICT-2014-1 - Photonics KET - Biophotonics for screening of diseases: Mobile, low-cost point-of-care screening devices for reliable, fast and non- or minimally-invasive detection of diseases.

Deliverables

List of deliverables.
Business plan	Documents, reports	2019-05-30 17:02:34
Report on novel developments and preliminary exploitation plan	Documents, reports	2019-05-30 17:02:30
Final exploitation plan and technology roadmap	Documents, reports	2019-05-30 17:02:27

Take a look to the deliverables list in detail: detailed list of RAIS deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2017	Filiz Yesilkoy, Roland A Terborg, Josselin Pello, Alexander A Belushkin, Yasaman Jahani, Valerio Pruneri, Hatice Altug Phase-sensitive plasmonic biosensor using a portable and large field-of-view interferometric microarray imager published pages: 17152, ISSN: 2047-7538, DOI: 10.1038/lsa.2017.152	Light: Science & Applications 7/2	2019-05-30
2016	R. A. Terborg, J. Pello, I. Mannelli, J. P. Torres, V. Pruneri Ultrasensitive interferometric on-chip microscopy of transparent objects published pages: e1600077-e160007, ISSN: 2375-2548, DOI: 10.1126/sciadv.1600077	Science Advances 2/6	2019-05-30
2016	Odeta Limaj, Dordaneh Etezadi, Nathan J. Wittenberg, Daniel Rodrigo, Daehan Yoo, Sang-Hyun Oh, Hatice Altug Infrared Plasmonic Biosensor for Real-Time and Label-Free Monitoring of Lipid Membranes published pages: 1502-1508, ISSN: 1530-6984, DOI: 10.1021/acs.nanolett.5b05316	Nano Letters 16/2	2019-05-30

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