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NEURO-PATTERNS SIGNED

How neuronal activity patterns drive behavior: novel all-optical control and monitoring of brain neuronal networks with high spatiotemporal resolution

Total Cost €

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EC-Contrib. €

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Partnership

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Project "NEURO-PATTERNS" data sheet

The following table provides information about the project.

Coordinator
FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA 

Organization address
address: VIA MOREGO 30
city: GENOVA
postcode: 16163
website: www.iit.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 1˙974˙000 €
 EC max contribution 1˙974˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-CoG
 Funding Scheme ERC-COG
 Starting year 2015
 Duration (year-month-day) from 2015-10-01   to  2020-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA IT (GENOVA) coordinator 1˙637˙500.00
2    THE UNIVERSITY OF CHICAGO US (CHICAGO ILLINOIS) participant 336˙500.00

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 Project objective

When we see an object, hear a sound or smell an odor, precise spatial and temporal patterns of electrical activity are generated within neuronal networks located in specialized brain areas. This electrical representation of the external stimulus mediates perception and sensory experience. However, this process is highly variable, and repetition of the very same sensory experience results in distinct network activity patterns. What does this variability mean for perception? Do distinct activity patterns carry different information about the stimulus? Or rather, does the brain code the same information coming from the outside world in multiple and equivalent ways? Answering these questions and determining how patterns of activity in neuronal populations are used for behavior has not been possible because of the inability to change the activity of neurons with single cell precision over large networks in an intact mammalian brain. In this ambitious proposal we will take a multidisciplinary approach to causally address these questions and decipher the computational principles of brain networks. To achieve this goal we will develop innovative optical technologies for manipulating and monitoring brain circuits with single cell resolution in the intact mouse brain. We will combine these new techniques with novel genetic manipulations and psychophysical behavioral methods that allow precise quantification of animals’ perceptual performance. Using this unique set of tools, we will unravel how the spatial (across neurons) and temporal (across time) aspects of neuronal electrical activity patterns encode information that guides behavior. In achieving our goals we will produce a new technology for stimulating and monitoring neurons in the brains of behaving animals with single-cell specificity that can be adapted to explore cellular dynamics in highly scattering biological media.

 Publications

year authors and title journal last update
List of publications.
2016 Claudio Moretti, Andrea Antonini, Serena Bovetti, Carlo Liberale, Tommaso Fellin
Scanless functional imaging of hippocampal networks using patterned two-photon illumination through GRIN lenses
published pages: 3958, ISSN: 2156-7085, DOI: 10.1364/boe.7.003958
Biomedical Optics Express 7/10 2019-06-06
2017 Panzeri S, Harvey CD, Piasini E, Latham PE, Fellin T
Cracking the Neural Code for Sensory Perception by Combining Statistics, Intervention, and Behavior
published pages: , ISSN: 0896-6273, DOI: 10.1016/j.neuron.2016.12.036
Neuron 2019-06-06
2017 Serena Bovetti, Claudio Moretti, Stefano Zucca, Marco Dal Maschio, Paolo Bonifazi, Tommaso Fellin
Simultaneous high-speed imaging and optogenetic inhibition in the intact mouse brain
published pages: 40041, ISSN: 2045-2322, DOI: 10.1038/srep40041
Scientific Reports 7 2019-06-06
2017 Stefano Zucca, Giulia D’Urso, Valentina Pasquale, Dania Vecchia, Giuseppe Pica, Serena Bovetti, Claudio Moretti, Stefano Varani, Manuel Molano-Mazón, Michela Chiappalone, Stefano Panzeri, Tommaso Fellin
An inhibitory gate for state transition in cortex
published pages: , ISSN: 2050-084X, DOI: 10.7554/eLife.26177
eLife 6 2019-06-06
2016 De Stasi AM, Farisello P, Marcon I, Cavallari S, Forli A, Vecchia D, Losi G, Mantegazza M, Panzeri S, Carmignoto G, Bacci A, Fellin T
Unaltered Network Activity and Interneuronal Firing During Spontaneous Cortical Dynamics In Vivo in a Mouse Model of Severe Myoclonic Epilepsy of Infancy.
published pages: 1778-1794, ISSN: 1047-3211, DOI: 10.1093/cercor/bhw002
Cerebral Cortex 26/4 2019-06-06

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